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    • A Farewell to Flat Biology. Three-dimensional Cell Culture Models in Cancer Drug Target Identification and Validation 

      Härmä, Ville
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1028 (Turun yliopisto, 14.09.2012)
      Cells of epithelial origin, e.g. from breast and prostate cancers, effectively differentiate into complex multicellular structures when cultured in three-dimensions (3D) instead of conventional two-dimensional (2D) adherent ...

    • A Systems Biology Analysis of PP2A Functions in Cancer Cells 

      Kauko, Otto
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1264 (Turun yliopisto, 20.01.2017)
      Cancer is characterized by aberrant activation of phosphorylation signalling cascades. However, despite the critical role of phosphatases in protein phosphorylation, their contribution to cancer cell signalling is only ...

    • Actin- and adhesion-mediated regulation of cell states : from cancer to stem cells 

      Taskinen, Maria
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1670 (Turun yliopisto, 28.10.2022)
      Actin cytoskeleton and cell adhesion regulate cell shape, contractility and motility, all of which play important roles in development of normal tissues and diseases. Integrins are adhesion receptors that are connected ...

    • Alpha- and gamma-melanocyte stimulating hormones in obesity. A study of the key central areas of metabolic regulation 

      Eerola, Kim
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1128 (Turun yliopisto, 19.09.2014)
      The melanocortin system is an important regulator of feeding, energy metabolism,and cardiovascular function and it consists of the pro-opiomelanocortin (POMC) derived melanocyte stimulating hormones (α-, β- and γ-MSH) and ...

    • Alpha2-Adrenoceptor-mediated vascular responses induced by dexmedetomidine 

      Posti, Jussi P.
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1017 (Turun yliopisto, 15.06.2012)
      Alpha2-Adrenoceptors are cell-surface G protein coupled receptors that mediate many of the effects of the catecholamines noradrenaline and adrenaline. The three human α2-adrenoceptor subtypes are widely expressed in different ...

    • Analyzing change in medication use - statistical approaches 

      Lavikainen, Piia
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1241 (Turun yliopisto, 12.08.2016)
      The objective of this study was to gain an understanding of the effects of population heterogeneity, missing data, and causal relationships on parameter estimates from statistical models when analyzing change ...

    • Androgen receptor therapy resistance in prostate cancer: From the disease model to the mechanisms 

      Huhtaniemi, Riikka
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica - Odontologica : 1782 (Turun yliopisto, 08.03.2024)
      Androgens act through the androgen receptor (AR) and are critical regulators of prostate differentiation and function, as well as prostate cancer (PCa) growth and survival. The development of treatment resistance in ...

    • ANDROGEN SIGNALING AXIS AS DRUG TARGET IN CASTRATION-RESISTANT PROSTATE CANCER: Preclinical development of novel treatments and models 

      Oksala, Riikka
      Turun yliopiston julkaisuja. Sarja D, Medica - Odontologica : 1364 (Turun yliopisto, 15.06.2018)
      Abstract: Prostate cancer is a major global challenge due to the increasing number of aging population and frequency of diagnosis. Already in 1941, Huggins and Hodges showed that metastatic prostate cancer is responsive ...

    • ANO7 in aggressive prostate cancer 

      Kaikkonen, Elina
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1470 (Turun yliopisto, 13.03.2020)
      A significant proportion of men develop prostate cancer during their lifetime, which causes challenges for public health. PSA screening studies have shown that testing all men at specific ages causes overdiagnosis of ...

    • Antigen processing and intercellular trafficking in B cells 

      Runsala, Marika
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica-Odontologica : 1657 (Turun yliopisto, 30.09.2022)
      B cells are responsible for specific antibody production. To produce antibodies, they recognize and internalize antigen (ag), cleave it into peptides, load the peptideantigens (pAg:s) onto major histocompatibility complex ...

    • Antiviral modified siRNA swarms for treatment of herpes simplex virus infection 

      Kalke, Kiira
      Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odontologica : 1689 (Turun yliopisto, 17.03.2023)
      Herpes simplex virus type 1 (HSV-1) is a common virus of humans carried by half of the global population. After the primary infection, HSV has the ability to establish life-long latency, wherefrom it can reactivate. The ...

    • Application of RNAi to silence tartrate-resistant acid phosphatase: unexpected effects on the monocyte-macrophage lineage 

      Muhonen, Pirkko
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 766 (Turun yliopisto, 02.11.2007)
      <b>Tartraatti-resistentin happaman fosfataasin hiljentäminen RNAi menetelmällä: odottamaton vaikutus monosyytti-makrofagi linjan soluissa</b> RNA interferenssi (RNAi) eli RNA:n hiljentyminen löydettiin ensimmäisenä ...

    • Assay development and study of a mutation affecting gonadotropin action 

      Trehan, Ashutosh
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1246 (Turun yliopisto, 23.09.2016)
      The gonadotropin action mediated via three glycoprotein hormones, luteinizing hormone (LH), chorionic gonadotropin (CG) and follicle-stimulating hormone (FSH) is paramount for sexual differentiation, pubertal development ...

    • B Cell Activation and Antibody Responses: The role of vesicle trafficking and Rab GTPases 

      Hernández Pérez, Sara
      Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odontologica : 1645 (Turun yliopisto, 12.08.2022)
      B lymphocytes are an important part of the adaptive immune system. As one of their main functions, B cells can recognise specific antigens via their B cell receptor and produce antibodies that help clear infections. In ...

    • B cell-mediated immunity and signal regulation. The roles of MIM/MTSS1 and IRF4 

      Sarapulov, Alexey
      Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odontologica : 1615 (Turun yliopisto, 11.03.2022)
      B cells constitute an important part of the adaptive immune system and produce antibodies, which protect organism against infectious agents. Recognition of the antigen by the B cell receptor and the following B cell ...

    • Bioimage informatics in STED super-resolution microscopy 

      Koho, Sami
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1219 (Turun yliopisto, 04.03.2016)
      Optical microscopy is living its renaissance. The diffraction limit, although still physically true, plays a minor role in the achievable resolution in far-field fluorescence microscopy. Super-resolution ...

    • Bioinformatics of human picornavirus molecular evolution and pathogenesis 

      Hietanen, Eero
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica-Odontologica : 1676 (Turun yliopisto, 16.12.2022)
      Picornaviruses are a family of small, non-enveloped, positive-sense single-stranded RNA viruses. Together they form group of viruses that in humans cause diseases such as poliomyelitis, encephalitis, hand-foot-and-mouth ...

    • Biological imaging of challenging targets: Peripheral nerve, mouse bones and cultured osteoclasts 

      Alanne, Maria
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica-Odontologica : 1554 (Turun yliopisto, 25.05.2021)
      During this study, advances in bioimaging have affected the biomedical research field. In this thesis, traditional microscopy and selected new techniques, namely microcomputed tomography (µCT), STED microscopy and ...

    • Biomarkers in stage II colorectal cancer 

      Slik, Khadija
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1460 (Turun yliopisto, 21.02.2020)
      The risk of recurrence of stage II colorectal cancer is difficult to predict. A part of recurrences take place among patients without any of the known high-risk factors such as lymphovascular invasion or preoperative ...

    • Biosynthesis of Yersinia enterocolitica serotype O:3 lipopolysaccharide outer core 

      Pinta, Elise
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 927 (Turun yliopisto, 19.11.2010)
      Lipopolysacharide (LPS) present on the outer leaflet of Gram-negative bacteria is important for the adaptation of the bacteria to the environment. Structurally, LPS can be divided into three parts: lipid A, core and ...