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Effects of Silica Based Biomaterials on Bone Marrow Derived Cells - Material Aspects of Bone Regeneration
(Annales Universitatis Turkuensis D 956Turun yliopisto, 2011-04-01)
Silica based biomaterials, such as melt-derived bioactive glasses and sol-gel glasses, have been used for a long time in bone healing applications because of their ability to form hydroxyapatite and to stimulate stem cell ...
Transcriptional Profiling of Organ‐Specific Autoimmunity in Human
(Annales Universitatis Turkuensis D 983Turun yliopisto, 2011-11-04)
Our understanding of the pathogenesis of organ‐specific autoinflammation has been restricted by limited access to the target organs. Peripheral blood, however, as a preferred transportation route for immune cells, provides ...
Regulation of B Cell Gene Expression and Function by Ikaros, Helios and Bcl6
(Annales Universitatis Turkuensis D 935Turun yliopisto, 2010-12-17)
B lymphocytes constitute a key branch of adaptive immunity by providing specificity to recognize a vast variety of antigens by B cell antigen receptors (BCR) and secreted antibodies. Antigen recognition activates the cells ...
Functional characterization of proteins required for mitotic progression and the spindle assembly checkpoint
(Annales Universitatis Turkuensis D 933Turun yliopisto, 2010-12-03)
During mitotic cell division, the genetic material packed into chromosomes is divided equally between two daughter cells. Before the separation of the two copies of a chromosome (sister chromatids), each chromosome has to ...
Targeting Adenoviral Gene Therapy Vectors to Head and Neck Squamous Cell Carcinoma and Heart
(Annales Universitatis Turkuensis D 937Turun yliopisto, 2010-12-03)
Gene therapy aims to treat diseases by introducing genetic material to the diseased tissue. For cancer treatment it is important to destroy cancerous cells; this can be achieved by introducing a gene, which induces cell ...
Generation and Characterization of Knockout Mice and Analysis of Patient Material Demonstrates a Role for Tissue Inhibitor of Metalloproteinases 4 (Timp4) in the Cardiovascular System and Tumor Metastasis
(Annales Universitatis Turkuensis D 1027Turun yliopisto, 2012-08-31)
This thesis focuses on tissue inhibitor of metalloproteinases 4 (TIMP4) which is the
newest member of a small gene and protein family of four closely related endogenous
inhibitors of extracellular matrix (ECM) degrading ...
Molecular diagnostics of rare inherited SYNDROMES with a view on diagnostic test development
(Annales Universitatis Turkuensis D 1024Turun yliopisto, 2012-08-24)
CHARGE syndrome, Sotos syndrome and 3p deletion syndrome are examples of
rare inherited syndromes that have been recognized for decades but for which the
molecular diagnostics only have been made possible by recent ...
Bone Health, Osteoporosis and Fracture Risk in Neurofibromatosis 1 - An Emphasis on Osteoclasts
(Annales Universitatis Turkuensis D 1013Turun yliopisto, 2012-06-29)
Neurofibromatosis 1 (NF1) is an autosomal dominant hereditary syndrome, affecting skin, neural tissues and skeleton. Hallmarks of NF1 include benign cutaneous neurofibroma tumors, pigmentation lesions on the skin and in ...
Identification of Epigenetic Targets in Prostate Cancer for Therapeutic Development
(Annales Universitatis Turkuensis D 1057Turun yliopisto, 2013-03-01)
Recurrent castration resistant prostate cancer remains a challenge for cancer therapies
and novel treatment options in addition to current anti-androgen and mitosis inhibitors
are needed. Aberrations in epigenetic enzymes ...
The Dual Role of HIF Hydroxylase PHD3 in Cancer Cell Survival
(Annales Universitatis Turkuensis D 1033Turun yliopisto, 2012-10-12)
Most advanced tumours face periods of reduced oxygen availability i.e. hypoxia.
During these periods tumour cells undergo adaptive changes enabling their survival
under adverse conditions. In cancer hypoxia-induced ...