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Aineistot 261-270 / 578
Comparison of DNA damage biomarker dynamics after induced DNA damage : Study of DNA damage biomarker expression and dynamics in cancer cells
(2022-05-02)
To ensure genomic integrity and protect cells from a variety of DNA damaging agents, cells have developed a complex network called the DNA damage response (DDR). It monitors and ensures DNA integrity by coordinating DNA ...
System-wide approaches to uncover Th2 cell lineage commitment
(Annales Universitatis Turkuensis D 1040Turun yliopisto, 2012-10-26)
T helper (Th) cells are vital regulators of the adaptive immune system. When
activated by presentation of cognate antigen, Th cells demonstrate capacity to
differentiate into functionally distinct effector cell subsets. ...
The iron-entry pores in Dps-like proteins as a potential drug-design targe: Structural investigations
(2022-06-01)
Streptococcus suis is an emerging catalase-negative zoonotic pathogen that uses the peroxide resistance protein (Dpr) as a defensive mechanism against oxidative stress. Dpr belongs to a family of proteins that form spherical ...
Contribution of BIM Serine 87 phosphorylation on targeted therapy response
(2022-06-06)
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are the standard-of-care for the treatment of EGFR-mutant non-small cell lung cancer (NSCLC) with typically excellent response rates. However, no ...
B Cell Activation and Antibody Responses: The role of vesicle trafficking and Rab GTPases
(Turun yliopisto, 2022-08-12)
B lymphocytes are an important part of the adaptive immune system. As one of their main functions, B cells can recognise specific antigens via their B cell receptor and produce antibodies that help clear infections. In ...
Subjective listening experiments for annoyance investigation
(Turun yliopisto, 2022-09-16)
Noise limits and guidelines that consider only the sound pressure level or the loudness of noises are not efficient in protecting people from all the adverse effects of noise. Other physical characteristics, e.g., tonality, ...
Visualization of cellular surface and intercellular structures of human pluripotent stem cells using electron microscopy techniques
(2022-05-02)
Human Induced Pluripotent Stem Cells (hiPSCs) are a classification of stem cells that has the prospect of differentiating into any cell kind in the human body. In his lab in Kyoto, Japan, Shinya Yamanaka 2006 discovered ...
Unen ja lihavuuden yhteys lapsuudessa
(2022-02-22)
Tämän tutkielman aiheena on unen ja lihavuuden välinen yhteys lapsuudessa. Päätavoitteena on selvittää unen eri komponenttien ja lihavuuden välisiä yhteyksiä lapsuudessa, arvioiden etenkin yhteyksien taustalla vaikuttavia ...
Morbidity in neurofibromatosis 1: Epidemiological perspectives on breast cancer and diabetes
(Turun yliopisto, 2022-05-20)
Neurofibromatosis type 1 (NF1) is a dominantly inherited rare disorder caused by pathogenic variants of the NF1 tumor suppressor gene. The syndrome can be diagnosed based on its clinical manifestations, such as café-au-lait ...
Searching for activating ERBB2 mutations with a high throughput screen
(2021-12-03)
There are numerous reports of ERBB mutations in various cancer types. Majority of the identified cancer-associated mutations usually accumulate in certain functional areas of these genes, called hotspots, and the frequency ...