fi=3. UTUCris-artikkelit|en=3. UTUCris-articles|
https://www.utupub.fi:443/handle/10024/153169
2024-03-28T12:11:06ZAssociation of Toll-like receptor 2 rs111200466 polymorphism with low serum levels of IL-33 in early childhood
https://www.utupub.fi:443/handle/10024/175070
Association of Toll-like receptor 2 rs111200466 polymorphism with low serum levels of IL-33 in early childhood
Teräsjärvi Johanna T.; Peltola Ville; Mertsola Jussi; He Qiushui; Toivonen Laura
<p>TLR2 is one of 10 human TLRs, which plays an important role in the recognition of pathogens and activation of the innate immunity via NF-κB pathway. NF-κB activation induces the expression of various pro-inflammatory genes. This study examines the effect of TLR2 polymorphisms on the production of blood pro-inflammatory cytokines in healthy Finnish children. One hundred forty-six children who participated in a prospective observational birth cohort study in Turku, Finland, were included. DNA samples were analysed by PCR-based sequencing for two common TLR2 polymorphisms (rs5743708 Arg753Gln; rs111200466–196 to –174del). Serum concentrations of IL-33, IL-31, IL-17A and IL-17F were measured by multiplex immunoassay and sST2 by ELISA in children at the age of 13 months. Children with variant type of TLR2 rs111200466 (ins/del or del/del) had significantly lower level of serum IL-33 (median, 0.00 pg/mL; IQR 0.00–17.60) than those with ins/ins type of TLR2 (19.81 pg/mL; IQR 0.00–51.78) (p = 0.0001). Almost all study subjects had serum concentrations of IL-17A, IL-17F and IL-31 below the detection limit and therefore not included in the final analyses. No differences in levels of above four cytokines and sST2 were found between TLR2 rs5743708 genotypes (GG and GA). Our results indicated that the TLR2 rs111200466 deletion was associated with a low level of serum IL-33, suggesting that the polymorphism may impair the production of IL-33.<br></p>
Pelvic organ prolapse after hysterectomy: A 10-year national follow-up study
https://www.utupub.fi:443/handle/10024/175069
Pelvic organ prolapse after hysterectomy: A 10-year national follow-up study
Mäkinen Juha; Harkki Päivi; Jalkanen Jyrki; Rahkola-Soisalo Päivi; Brummer Tea; Kuittinen Tea; Sjöberg Jari; Mentula Maarit; Tulokas Sari; Tomas Eija
<p><strong>Introduction: </strong>Hysterectomy may have an effect on the pelvic floor. Here, we evaluated the rates and risks for pelvic organ prolapse (POP) surgeries and visits among women with a history of hysterectomy for benign indication excluding POP.</p><p><strong>Material and methods: </strong>In this retrospective cohort study 3582 women who underwent hysterectomy in 2006 were followed until the end of 2016. The cohort was linked to the Finnish Care Register to catch any prolapse-related diagnoses and operation codes following the hysterectomy. Different hysterectomy approaches were compared according to the risk for a prolapse, including abdominal, laparoscopic, laparoscopic-assisted vaginal and vaginal. The main outcomes were POP surgery and outpatient visit for POP, and Cox regression was used to identify risk factors (hazard ratios [HR]).</p><p><strong>Results: </strong>During the follow-up, 58 women (1.6%) underwent a POP operation, of which a posterior repair was the most common (n = 39, 1.1%). Outpatient visits for POP symptoms occurred in 92 (2.6%) women of which posterior wall prolapses (n = 58, 1.6%) were the most common. History of laparoscopic-assisted vaginal hysterectomy were associated with risk for POP operation (HR 3.0, p = 0.02), vaginal vault prolapse operation (HR 4.3, p = 0.01) and POP visits (HR 2.2, p < 0.01) as compared to the approach of abdominal hysterectomy. History of vaginal deliveries and concomitant stress urinary continence operation were associated with the risk for a POP operation (HR 4.4 and 11.9) and POP visits (HR 3.9 and 7.2).</p><p><strong>Conclusions: </strong>Risk for POP operations and outpatient visits for POP symptoms in hysterectomized women without a preceding POP seems to be small at least 10 years after hysterectomy. History of LAVH, vaginal deliveries and concomitant stress urinary incontinence operations increased the risk for POP operations after hysterectomy. These data can be utilized in counseling women considering hysterectomy for benign indication.</p>
Toward Finnish Heterolinational Literatures: Challenges and Opportunities
https://www.utupub.fi:443/handle/10024/175046
Toward Finnish Heterolinational Literatures: Challenges and Opportunities
Ghasemi Mehdi
On the Möbius function in all short intervals
https://www.utupub.fi:443/handle/10024/175027
On the Möbius function in all short intervals
Matomäki Kaisa; Teräväinen Joni