Selaus laitoksen mukaan kokoelmassa Pro gradu -tutkielmat ja diplomityöt sekä syventävien opintojen opinnäytetyöt (kokotekstit) Bioteknologian laitos
Aineistot 1-20 / 42
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Analysis of volatile aroma-active compounds from a headspace of a novel whiskey glass
(31.05.2022)In the literature part of this thesis the human olfactory sense is explored. Also, individual differences in the sense of smell are studied. Since the study focuses on whiskey the anesthetic effects of ethanol on the ...avoin -
Antiviral activity of enzymatically synthesized siRNA swarms against herpes simplex virus type 2 clinical strains
(17.06.2021)HSV-1 and HSV-2 are closely related human pathogens that share approximately 50% overall sequence homology and cause latent infections recurring as orofacial and genital herpes. Recently a novel treatment modality was ...avoin -
BilRI-proteiinin ilmentyminen yksittäisissä Aggregatibacter actinomycetemcomitans -soluissa
(07.02.2024)Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) on gramnegatiivinen opportunistinen patogeeni, joka aiheuttaa ihmisessä parodontiittia, vakavaa hampaan kiinnityskudoksen sairautta. A. actinomycetemcomitans ...avoin -
Comparison of odour-active compounds in raw Baltic herring with pH-shift produced protein isolate using gas chromatography olfactometry
(28.04.2023)Baltic herring is used in a limited capacity for human consumption in Finland even though it has largest annual catch out of other fish species. There is a substantial amount of interest in improving the rate of consumption ...avoin -
Construction and functional validation of combinatorial designed ankyrin repeat protein (DARPin) libraries for phage display
(29.05.2023)Designed ankyrin repeat protein (DARPin) is one of the most advanced alternative scaffold proteins. In this study, a combinatorial DARPin library for phage display was constructed. Firstly, a binary DARPin phage display ...avoin -
Developing and optimizing microfluidics platform for fabricating lignin nanoparticles.
(21.01.2021)Introduction: Lignin is a complex organic polymer, produced in large quantities as a by-product from pulp and paper industries. Despite of large-scale production, lignin is not being utilized for high value applications. ...avoin -
Development of Lingonberry Wines with a Sensomics approach
(20.04.2023)Albeit categorization of lingonberry as a superfruit courtesy of its bioactive composition, valorisation of the superfruit has remained sub-par ascribed to the challenging flavour profile. In addition, lingonberry fermentation ...avoin -
Differential gene expression analysis of aclacinomycin producing Streptomyces galilaeus ATCC 31615 and its mutant
(25.05.2021)Streptomyces from the genus Actinomycetales are soil bacteria known to have a complex secondary metabolism that is extensively regulated by environmental and genetic factors. Consequently they produce antibiotics that are ...avoin -
Discovery of novel antibiotics by metabolic engineering of Streptomyces soil bacteria
(02.06.2023)Antimicrobial resistance is a rapidly developing threat that has been estimated to kill 10 million people yearly by 2050. This underscores the urgent need for novel antibiotics that do not share cross-resistance with ...avoin -
DNA methylome and transcriptome changes caused by glucocorticoid treatment in T- cell acute lymphoblastic leukemia cells
(21.05.2021)Leukemia is a type of blood cancer and one of the most common pediatric cancers. T cell acute lymphoblastic leukemia (T-ALL) accounts for nearly 10-15 % and among pediatric patients. Chemotherapy is widely used to treat ...avoin -
Early detection of prostate cancer using extracellular vesicles and nanoparticle-aided time-resolved fluorescence immunoassay
(28.06.2023)Prostate cancer (PCa) is a type of cancer that affects the prostate, an organ in the male reproductive system. It is mostly diagnosed and deadliest cancers among men. In 2020, approximately 1.4 million new cases were ...avoin -
Effect of yeast strains on the chemical composition of ciders from Finnish apple cultivars
(02.01.2024)Effect of Saccharomyces and non- Saccharomyces yeast in apple ciders and juices were studied using Gas chromatography fitted with Flame Ionization Detector. Samples were produced from six different Finnish apple cultivars ...avoin -
ELISA-menetelmien hyödyntäminen kosteusvaurioiden aiheuttamien immunologisten vasteiden tutkimuksessa
(05.11.2021)Suuressa osassa rakennuksia ilmenee jossain niiden elinkaaren aikana kosteusvaurioita, joissa usein havaitaan mikrobikasvustoa. Kuivuessa mikrobipartikkelit saattavat emittoitua kasvustosta sisäilmaan ja dormantit partikkelit ...avoin -
Embigiinin hiljennys häiritsee hiiren keratinosyyttien aineenvaihduntaa
(29.04.2021)Embigiini (GP-70) on solujen pinnoilla esiintyvä, kalvon läpäisevä glykoproteiini. Se osallistuu solujen kiinnittymiseen soluväliaineeseen ja vaikuttaa solujen aineenvaihduntaan. Sillä on erityisen tärkeä rooli pienten ...avoin -
Embigiinin tehtävien kartoitus siRNA-hiljennyksen avulla : munuaisten sekä putkimaisten rakenteiden kehitys
(25.05.2021)Embigiini (GP70) on transmembraaninen glykoproteiini. Embigiiniä on löydetty kiveksistä, lisäkiveksistä, munuaisista, ihosta sekä keuhkoista. Hiirillä embigiiniä ilmentyy alkionkehityksen aikana paljon ja iän myötä sen ...avoin -
Expression, purification, and characterisation of a novel bacterial ADP-ribosyltransferase
(24.05.2023)ADP-ribosylation is a chemical modification that is mostly known as a post-translational modification targeting nucleophilic amino acid residues. It utilizes the common coenzyme NAD+ as the reactant. The reaction is catalysed ...avoin -
Extracellular matrix proteins in hypoxia, 3D cancer spheroids as a model
(07.12.2022)The extracellular matrix (ECM) is a non-cellular network of cross-linked macromolecules, such as collagens, glycoproteins (fibronectin and laminins), and proteoglycans. The ECM plays a critical role in mediating cell ...avoin -
Fermentation of lupin with lactic acid bacteria using a bioreactor
(16.02.2024)The rising interest in incorporating lupin into our diet is driven by its unique nutritional value, notably its high protein content, coupled with its sustainability. Fermentation is a natural bioprocess widely employed ...avoin -
Fysikaalisten ja kemiallisten tekijöiden vaikutus ihmisen komplementtisysteemin reaktioteiden aktiivisuuteen - menetelmän hyödyntäminen sisäilmaongelmaisten tilankäyttäjien altistuksen toteamiseen
(13.09.2022)Komplementtisysteemi on osa selkärankaisten immuunijärjestelmää ja toimii ensimmäisenä puolustuskeinona mikrobi-infektioissa. Sen tärkeimpiä tehtäviä on patogeenin lyysaus, leukosyyttivasteen aktivointi ja opsonisaatio. ...avoin -
Generation of HOXB13G84E cellular models with prime editing
(07.05.2021)Prostate cancer (PCa) is the second most common cancer in men and the fifth leading cause of cancer-related death in men. PCa is a highly heritable disease and genetic factors explain 58 % of the risk. Studies on PCa have ...avoin