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Production and optimization of cell-specific and brain-targeted recombinant adeno-associated virus tools for target validation in Parkinson’s disease models
(2022-05-12)
Parkinson’s disease (PD) is a heterogeneous disorder associated with the progressive loss of dopaminergic neurons in specific brain regions. The underlying molecular events in PD result from the complicated interplay of ...
Developing and optimizing microfluidics platform for fabricating lignin nanoparticles.
(2021-01-21)
Introduction: Lignin is a complex organic polymer, produced in large quantities as a by-product from pulp and paper industries. Despite of large-scale production, lignin is not being utilized for high value applications. ...
DNA methylome and transcriptome changes caused by glucocorticoid treatment in T- cell acute lymphoblastic leukemia cells
(2021-05-21)
Leukemia is a type of blood cancer and one of the most common pediatric cancers.
T cell acute lymphoblastic leukemia (T-ALL) accounts for nearly 10-15 % and among pediatric patients. Chemotherapy is widely used to treat ...
Differential gene expression analysis of aclacinomycin producing Streptomyces galilaeus ATCC 31615 and its mutant
(2021-05-25)
Streptomyces from the genus Actinomycetales are soil bacteria known to have a complex secondary metabolism that is extensively regulated by environmental and genetic factors. Consequently they produce antibiotics that are ...
Validating Guide RNA Hits For Improving CRISPRa-Reprogramming
(2021-02-10)
Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by ectopically overexpressing the transcription factors OCT4, SOX2, KLF4 and c-Myc. This technique has since its invention been a topic of intense ...
Antiviral activity of enzymatically synthesized siRNA swarms against herpes simplex virus type 2 clinical strains
(2021-06-17)
HSV-1 and HSV-2 are closely related human pathogens that share approximately 50% overall sequence homology and cause latent infections recurring as orofacial and genital herpes. Recently a novel treatment modality was ...
Extracellular matrix proteins in hypoxia, 3D cancer spheroids as a model
(2022-12-07)
The extracellular matrix (ECM) is a non-cellular network of cross-linked macromolecules, such as collagens, glycoproteins (fibronectin and laminins), and proteoglycans. The ECM plays a critical role in mediating cell ...
Early detection of prostate cancer using extracellular vesicles and nanoparticle-aided time-resolved fluorescence immunoassay
(2023-06-28)
Prostate cancer (PCa) is a type of cancer that affects the prostate, an organ in the male
reproductive system. It is mostly diagnosed and deadliest cancers among men. In 2020,
approximately 1.4 million new cases were ...