Hae
Aineistot 1-10 / 73
Effect of melanocortin-1 receptor in the regulation of beta3-adrenoceptor agonist-induced BAT thermogenesis
(Turun yliopisto, 2019-03-01)
Adipose tissue is comprised of brown and white adipose tissues. In particular, brown adipose tissues (BAT) or brown fat contain rich amount of beta3-adrenoceptors (β3AR) and they are regulated by sympathetic nervous system ...
The role of the GABAA receptor δ subunit domains on agonist binding kinetics
(2019-11-27)
The GABAA receptor is a ligand-gated ion channel that conveys inhibitory signals in neurons. It is a pentameric receptor assembled from combinations of 19 subunits, however, most receptors are composed of α-, β- and ...
Towards targeting SAMHD1 to improve cytarabine therapy for hematological malignancies
(2018-09-26)
Acute myeloid leukemia (AML) is a hematological cancer where myeloid stem cells are transformed into malignant cells, filling and replacing the cells in a healthy bone marrow. Cytarabine is a nucleoside analog used in ...
In Vitro α-synuclein aggregation assay for studying induced cellular stress, drug targets and compounds
(2019-11-28)
Parkinson’s disease (PD) is most common movement disorder of the central nervous system in the world. Prevalence of PD increases by age, being 3000 per 100 000 in over 70 year olds. Pharmacological treatments of PD are ...
Treatment of herpes simplex virus infection using antiviral siRNA swarms with 2’-fluoro-modifications
(2020-04-28)
Herpes simplex virus 1 (HSV-1) is a very common pathogen. Besides mostly harmless oral lesions, HSV-1 causes severe diseases such as neonatal herpes, herpes encephalitis and herpes keratitis, the primary cause of infectious ...
An in vitro Model for Lysosomal Storage Diseases Using Aspartylglucosaminuria Patient Cells
(2020-04-28)
BACKGROUND Lysosomes are acidic organelles responsible for recycling of metabolic byproducts and cellular debris, and there are approximately 60 enzymes within lysosomes responsible for the recycling process. These enzymes ...
Radiosynthesis and biological evaluation of [68Ga]Ga-NOTA-Folate in experimental atherosclerosis and myocardial infarction models.
(2020-05-12)
While many folate-receptor (FR) targeting radiotracers have been studied for imaging cancers, there is a need for tracers that target inflammation for diagnostic and monitoring purposes. Two diseases in which inflammation ...
IMAGE DERIVED INPUT FUNCTION FOR BRAIN [11C]TMSX PET IMAGING
(2019-04-05)
Modeling and analysis of positron emission tomography (PET) imaging data requires the critical information of the input function of the radioligand used. In PET imaging of the brain, the ‘gold standard’ for acquiring input ...
Neural Structures Associated with Music Engagement in Persons with Alzheimer’s Disease
(2020-06-01)
Alzheimer’s disease (AD) is the most common cause of dementia and a major public health issue resulting in decreased life expectancy of patients and high societal cost. Medical treatment of AD is palliative in nature as ...
In-depth characterization of early stages of human induced regulatory T cell differentiation by mass cytometry
(2022-09-02)
Regulatory T cells (Tregs) are responsible for the maintenance of immunological homeostasis and self-tolerance. They are part of the CD4⁺ T helper (Th) cell population, but unlike other Th cells Tregs suppress immune ...