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Aineistot 101-110 / 145
Role of G-quadruplexes in targeting of somatic hypermutation
(2021-05-26)
Formation of high-affinity antibodies towards antigens is ensured with a process called somatic hypermutation, which happens during affinity maturation of activated B-cells. During this process point mutations are introduced ...
The Role of Beta Subunit Variant on the Properties of Delta-Containing Extrasynaptic GABAA Receptors
(Turun yliopisto, 2017-08-10)
Muscimol, a psychoactive constituent of Amanita muscaria, activates all GABAA receptor subtypes with exceptionally high affinity to αβδ. This is explained by δ subunit role on muscimol extremely slow dissociation from these ...
Auria Biopankin hyödynnettävyys tutkittavien rekrytoinnissa kliinisiin lääketutkimuksiin
(Turun yliopisto, 2016-08-19)
Kliininen lääketutkimus on ihmiseen kohdistuva interventiotutkimus, jonka tavoitteena on selvittää lääkeaineiden farmakodynaamisia sekä farmakokineettisiä ominaisuuksia ihmiselimistössä. Tutkittavien rekrytointi ...
INVESTIGATION OF LIGNIN NANOCAPSULES UPTAKE IN PLANTS
(2021-09-13)
The interest of the scientific community in nanotechnology has been growing significantly in the last decades, resulting in the development of new nanomaterials and nanoparticles which can find a wide variety of applications, ...
Analysis of angiogenic and antiangiogenic drugs in turquoise killifish and zebrafish wound healing models
(2021-09-14)
Impaired wound healing is an ever-increasing worldwide burden to human health affecting especially aged population. Wound healing is a complex process in which angiogenesis has a significant role. Recent data suggest that ...
Hyperthyroidism and Papillary Thyroid Carcinoma in Thyrotropin Receptor D633H Mutant Mice
(2021-03-26)
Background: Constitutively active thyrotropin receptor (TSHR) mutations are the most common etiology of non-autoimmune hyperthyroidism (NAH). Thus far, the functionality of these mutations has been tested in vitro, but the ...
Developing quantitative image analysis pipelines for scoring histological panoramic images : Testing Rab24 as a possible biomarker for cancer
(2021-05-18)
Biomarkers are highly essential to improve diagnosis, confirm the diseases' development, and monitor the treatment. Biomarker discovery requires analysis of a large quantity of data which is aided by computational tools. ...
Initiation of New Medication With an Actionable Pharmacogenetics-Based Prescribing Guideline in Discharged Hospital Patients in Finland
(2021-05-07)
OBJECTIVES. Purpose of this retrospective, register-based pharmacoepidemiologic study was to analyse post-discharge purchases of drugs with an actionable pharmacogenetics-based prescribing guideline with a patient cohort ...
The effect of melanocortin-1 receptor deficiency on cholesterol transporter genes in atherosclerotic ApoE knockout mouse model
(Turun yliopisto, 2017-07-20)
The melanocortin system comprises of melanocortin peptides; α-, β- and γ- melanocortin stimulating hormones (MSH) and adrenocorticotropic hormone (ACTH) derived from the proteolytic degradation ...
Characterization of Clever-1 expressing extracellular vesicles and their effect on T lymphocyte proliferation
(2021-05-10)
Immune checkpoint inhibitors (ICIs) are the new milestone for the management of advanced solid cancers. Unfortunately, most patients are not responsive to these treatments, since they may develop mechanisms that suppress ...