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Aineistot 11-20 / 40
Discovery of RAR-related Orphan Receptor γt Inverse Agonists
(2021-11-30)
BACKGROUND
Technological advances have provided modern approaches for drug discovery and development. Its application, computer-aided drug design (CADD), enables solving complex drug design challenges practically unsolvable ...
Specific immunoglobulin E analysis in adults presenting with birch pollen allergy symptoms
(2022-04-27)
The increase of IgE-mediated allergies and asthma is a socioeconomic challenge in developed countries. Although there are millions of people suffering from different types of allergies, they are often underdiagnosed, and ...
High throughput flow cytometry-based drug sensitivity testing for melflufen in multiple myeloma
(2020-09-04)
Multiple myeloma (MM) is a hematological plasma cell malignancy in the bone marrow. Lately, increased knowledge of MM pathogenesis and advances in therapy have improved the survival of MM patients. However, due to the ...
Precision Treatment of Acute Myeloid Leukemia : Predictive Response Biomarkers for BET inhibitor JQ1
(2018-09-19)
Acute myeloid leukemia (AML) is a hematological malignancy characterized by the accumulation of immature and abnormally proliferating blast cells in the patient’s bone marrow and peripheral blood. Despite the mounting ...
Effects of melanocortin receptor modulation on hypertrophic responses in cardiomyocytes
(2021-01-25)
After cardiac stress such as that occurring during myocardial infarction the heart undergoes pathological remodelling consisting of cardiomyocyte hypertrophy, interstitial fibrosis, contractile dysfunction, cell death and ...
In vitro co-culture models of peripheral blood derived cells and endothelial cells in angiogenesis
(2021-05-10)
Poor vascularization of tissue-engineered constructs is a common challenge in regenerative medicine and there is a need to find an optimal cell source that is proangiogenic and aids in the neovascularization process.
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The subcellular localization of myosin XVI in U2OS cells and its expression in the mouse brain
(2021-05-06)
Myosin XVI is a neuronally expressed member of the myosin superfamily. Many aspects of this myosin remain mysterious, but its ability to regulate actin branching and indications of its enhanced expression in early development ...
Late Chromatoid Body and its Role in RNA Regulation During Spermatid Elongation
(2021-05-04)
Spermatogenesis generates male gametes for reproduction. Spermiogenesis is the last part of spermatogenesis, where haploid male germ cells undergo differentiation from round spermatids to elongating spermatids and finally ...
In vitro bioactivity profile analysis and evaluation of usability of bioactive glass fibers as a structural part in load-bearing implants
(2020-12-08)
Metallic and permanent bone implants expose trauma patients to recurring fractures and infections even after years of implantation. Metallic implants also predispose for stress shielding phenomenon and fibrous capsule ...
Modulation of monocyte inflammatory response through estrogen receptor α and progesterone receptor signaling
(2021-04-06)
Ovarian hormone fluctuation has been associated to clinical status of several autoimmune conditions and the influence on inflammatory disease is under investigation. The incidence of inflammatory bowel disease is high in ...