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Aineistot 21-30 / 39
Establishment of in vitro breast cancer bone metastasis model using an artificial microenvironment
(2021-03-11)
Advanced breast cancer frequently metastasises to the bone, causing considerable morbidity to the patients. Survival rate after detection of bone metastases is poor, and options to treat bone metastases are insufficient. ...
Establishment of 3D co-culture model of mesenchymal stem cells and mononuclear cells for studying vasculogenesis/angiogenesis, and the magnetic isolation of endothelial progenitor cells from mononuclear cells
(2019-02-05)
Bone tissue engineering that stimulates bone formation has improved normal fracture healing, but its true clinical impact is still lacking. One of the biggest problems with bone tissue engineered grafts is an inadequate ...
Transport of statins by human ABC efflux transporters in vitro
(2021-04-26)
Transporters are cell membrane proteins, which mediate the cellular influx or efflux of compounds. Transporters expressed in tissues important for pharmacokinetics, can play a crucial role in drug absorption, distribution ...
Investigation of molecular interactions of prenylflavonoids at GABAA receptor subtypes
(2019-05-23)
Prenylated flavonoids derived from Hops (Humulus lupulus) activate the γ-aminobutyric acid (GABA) type A receptors through positive and negative modulation. Currently, these compounds’ binding site at the different GABAAR ...
Inhibition of the Nonessential Neurovirulence Gene of Herpes Simplex Virus Type 1 Using RNA Interference
(2021-05-04)
Herpes simplex virus type 1 (HSV-1) is a common pathogen that causes recurrent and latent infections in humans. The nonessential neurovirulence gene γ134.5 prevents cellular responses to an infection in differentiated host ...
FTIR and Raman spectroscopy in characterization of bioreactor cultured prostate cancer extracellular vesicles
(2021-03-15)
Background: Extracellular vesicles (EVs) are nano-sized cell membrane derived structures that function as intercellular messengers and hold potential for applications in diagnostics and drug delivery. There is a need to ...
Role of G-quadruplexes in targeting of somatic hypermutation
(2021-05-26)
Formation of high-affinity antibodies towards antigens is ensured with a process called somatic hypermutation, which happens during affinity maturation of activated B-cells. During this process point mutations are introduced ...
Analysis of angiogenic and antiangiogenic drugs in turquoise killifish and zebrafish wound healing models
(2021-09-14)
Impaired wound healing is an ever-increasing worldwide burden to human health affecting especially aged population. Wound healing is a complex process in which angiogenesis has a significant role. Recent data suggest that ...
Initiation of New Medication With an Actionable Pharmacogenetics-Based Prescribing Guideline in Discharged Hospital Patients in Finland
(2021-05-07)
OBJECTIVES. Purpose of this retrospective, register-based pharmacoepidemiologic study was to analyse post-discharge purchases of drugs with an actionable pharmacogenetics-based prescribing guideline with a patient cohort ...
Characterization of Clever-1 expressing extracellular vesicles and their effect on T lymphocyte proliferation
(2021-05-10)
Immune checkpoint inhibitors (ICIs) are the new milestone for the management of advanced solid cancers. Unfortunately, most patients are not responsive to these treatments, since they may develop mechanisms that suppress ...