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An in vitro Model for Lysosomal Storage Diseases Using Aspartylglucosaminuria Patient Cells
(2020-04-28)
BACKGROUND Lysosomes are acidic organelles responsible for recycling of metabolic byproducts and cellular debris, and there are approximately 60 enzymes within lysosomes responsible for the recycling process. These enzymes ...
Radiosynthesis and biological evaluation of [68Ga]Ga-NOTA-Folate in experimental atherosclerosis and myocardial infarction models.
(2020-05-12)
While many folate-receptor (FR) targeting radiotracers have been studied for imaging cancers, there is a need for tracers that target inflammation for diagnostic and monitoring purposes. Two diseases in which inflammation ...
IMAGE DERIVED INPUT FUNCTION FOR BRAIN [11C]TMSX PET IMAGING
(2019-04-05)
Modeling and analysis of positron emission tomography (PET) imaging data requires the critical information of the input function of the radioligand used. In PET imaging of the brain, the ‘gold standard’ for acquiring input ...
Neural Structures Associated with Music Engagement in Persons with Alzheimer’s Disease
(2020-06-01)
Alzheimer’s disease (AD) is the most common cause of dementia and a major public health issue resulting in decreased life expectancy of patients and high societal cost. Medical treatment of AD is palliative in nature as ...
In-depth characterization of early stages of human induced regulatory T cell differentiation by mass cytometry
(2022-09-02)
Regulatory T cells (Tregs) are responsible for the maintenance of immunological homeostasis and self-tolerance. They are part of the CD4⁺ T helper (Th) cell population, but unlike other Th cells Tregs suppress immune ...
Characterisation of the role of TLNRD1 in vascular development and integrity in zebrafish
(2022-09-05)
Angiogenesis, the formation of new blood vessels, is an essential process for vascular growth and blood vessel development. Defective regulation and abnormalities of angiogenesis are present in multiple diseases, such as ...
Hippo pathway activity after a peripheral nerve injury
(2022-04-14)
Transcriptional mechanisms underlying chronic neuropathic pain are still unclear. However, novel studies have suggested that the Hippo pathway and especially its compartments YAP and TAZ have a role in the pathology of ...
Applying Transfer Learning in Classification of Ischemia from Myocardial Polar Maps in PET Cardiac Perfusion Imaging
(2022-05-19)
Introduction: Ischemia is defined as the restriction of blood flow to a body organ, such as the heart, resulting in a cutback in oxygen supply. Myocardial ischemia is characterized by an imbalance between myocardial oxygen ...
In Vitro Characterization of Herpes Simplex Virus Type 1 Clinical Isolates with Respect to Their Potential as Gene Vectors
(2022-04-26)
Herpes simplex virus 1 (HSV-1) is a common human pathogen that can be found in approximately half of the population. Typically, it causes relatively mild symptoms such as cold sores, though HSV-1 can also enter a latent ...
Comparison of DNA damage biomarker dynamics after induced DNA damage : Study of DNA damage biomarker expression and dynamics in cancer cells
(2022-05-02)
To ensure genomic integrity and protect cells from a variety of DNA damaging agents, cells have developed a complex network called the DNA damage response (DDR). It monitors and ensures DNA integrity by coordinating DNA ...