Selaus laitoksen mukaan kokoelmassa Pro gradu -tutkielmat ja diplomityöt sekä syventävien opintojen opinnäytetyöt (rajattu näkyvyys) Biolääketieteen laitos
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[18F]FDG PET/CT imaging for evaluating associations between glycolytic activity of brown adipose tissue, breast cancer progression and cachexia in a xenograft model
(07.09.2023)BACKGROUND Brown adipose tissue (BAT) is a thermogenetic organ that helps to regulate body temperature. Besides the normal biological function of BAT, a relationship between BAT activity, cancer progression and cachexia ...suljettu -
A 3D co-culture assay to study the interaction of cancer-associated fibroblasts and immune cells in tumor microenvironment
(10.05.2024)Cancer-associated fibroblasts (CAFs) are the most prominent stromal cells of the tumor microenvironment, and their abundance has been linked to poor prognosis in several cancer types. CAFs play multiple roles in tumor ...suljettu -
A Framework for the Systematic Comparison of Classical Non-Learning, Machine Learning, and Artificial Intelligence Approaches to Cell Segmentation & Nuclei Detection in Histopathological Images
(03.08.2023)In the fields of diagnosis, digital pathology, and drug discovery, the characterization of tissue, in particular the cells, is crucial because it provides a fundamental understanding of the underlying cellular dynamics and ...suljettu -
Adipose tissue in health and disease – implications to cardiovascular diseases
(23.11.2020)Two major roles of adipose tissue are to function as a fat storage and an endocrine organ. Adipose tissue stores excess fat in adipocytes and releases when needed. Adipose tissue also secretes hormones, called adipokines, ...suljettu -
An in vitro model of hepatic steatosis and lipotoxicity – a focus on mitochondrial dysfunction and redox state
(26.05.2023)Non-alcoholic fatty liver disease (NAFLD) and alcohol-related fatty liver disease (ALD) have emerged as the leading causes of chronic liver disease worldwide. They cover a range of conditions from hepatic steatosis to ...suljettu -
Analysis of Rab24 protein expression in mouse tissues
(06.05.2020)Rab24 belongs to the Rab family of small GTPases that play important roles in intracellular vesicle formation, transportation, and fusion with target compartments. Almost 70 Rab proteins have been identified in humans so ...suljettu -
Androgen-oestrogen imbalance, obesity, and intestinal microbiota in AROM+ male mice
(17.03.2021)Androgens and oestrogens are sex hormones that produce sex-specific characteristics in males and females, respectively. However, sex hormones also possess far-reaching metabolic effects, which is evident in the comorbidity ...suljettu -
Antimicrobial and Biofilm Eradication Potential of Amine-Functionalized Polymeric Micelles
(05.05.2025)Antimicrobial resistance has been a growing concern of the 21st century affecting a major portion of the globe. It has further delved into playing a role in formation of biofilms in the process of chronic wound healing. ...suljettu -
Application of Optical Methods for Identification of Missense-Induced Deficits in SynGAP1
(09.05.2025)Disruptions in SynGAP1 function caused by mutations are linked to neurodevelopmental disorders. Most known pathogenic SynGAP1 variants act via truncation and frame shift mutations while the minority of diagnosed cases ...suljettu -
Association between chronic active lesions and gray matter pathology in multiple sclerosis
(22.04.2025)Multiple sclerosis (MS) is a leading cause of neurological disability particularly among young adults, traditionally considered a white matter (WM) disease. However, recent research highlights the role of gray matter (GM) ...suljettu -
Avian and Human Influenza A Virus Non-Structural Protein 1 in Innate Immune Response Inhibition
(21.05.2025)Influenza viruses are respiratory pathogens responsible for seasonal epidemics. In addition, influenza A viruses (IAVs), which infect a wide range of animals, can cause emerging zoonotic pandemics. Recently, the avian H5N1 ...suljettu -
Avohoidon MRSA-tapausten epidemiologia Turun alueella vuosina 2007-2016
(01.02.2021)Tämän syventävien opintojeni kohteeksi valikoitui avohoidon MRSA-tapaukset Turussa vuosina 2007-2016. Opinnäytetyöni on osa laajempaa TY:ssa ja VSSHP:ssa käynnissä olevaa MRSA-tutkimushanketta. MRSA-infektiot aiheuttavat ...suljettu -
Biomineralized mitochondrial transplantation corrects macrophage behaviour to suppress osteoporosis under breast cancer susceptibility
(06.05.2025)Osteoporosis caused by bone metastasis in breast cancer patients is often exacerbated by existing therapies, primarily leading to bone loss. Macrophages play a vital role in breast cancer-induced bone loss, where their ...suljettu -
Blocking Clever-1 on human monocytes inhibits the growth of aggressive breast cancer
(31.07.2019)Immunosuppressive tumor microenvironment limits antitumoral immunity and facilitates cancer progression. Tumor-associated macrophages that are mainly derived from blood monocytes, are central regulators of the tumor immune ...suljettu -
Breast cancer prevention by diet : The effect of dietary polyphenols on TNF-α mediated aromatase gene (CYP19A1) expression in breast stromal cells
(24.05.2021)The different ways to prevent postmenopausal breast cancer have been under investigation for years. The effects of menopause and obesity-related adipose tissue inflammation on estrogen biosynthesis are believed to promote ...suljettu -
CCL21 mediated dendritic cell migration: the role of self-generated chemokine gradients and Lfc
(15.05.2025)Dendritic cells (DCs) link innate and adaptive immune systems together by presenting antigens and activating T cells in lymph nodes. Antigen encounter leads to DC maturation and expression of CCR7, a receptor for chemokines ...suljettu -
CD206 in colon cancer
(17.03.2020)The assessment of immunologic milieu in cancer tissue has proven to be a powerful factor in estimation of disease outcome. The basic idea is to characterize the presence of different immune cell types within tumor tissue. ...suljettu -
CD47 and TREM2 for macrophage-targeted cancer immunotherapy: Antibody validation and ex vivo efficacy in patient-derived explant cultures
(13.03.2024)Cancer remains a common cause of death worldwide. Cancer cells develop several mechanisms to escape immune destruction, which limits the efficacy of current treatments and creates a need for new therapies. Cancer immunotherapies ...suljettu -
Cell signaling in breast cancer associated with neurofibromatosis type 1
(30.04.2020)Neurofibromatosis 1 (NF1) is an autosomal dominant disorder caused by mutations in the NF1 gene, which codes tumor suppressor protein neurofibromin. The incidence of NF1 is approximately 1:2000. Patients with NF1 are at ...suljettu -
CELL-TYPE SPESIFIC CD73 EXPRESSION IS AN INDEPENDENT PROGNOSTIC FACTOR IN BLADDER CANCER
(06.11.2018)CD73 is an adenosine-producing cell surface enzyme, which exerts strong anti-inflammatory and migration modulating effects in many cell types. We evaluated the potential of CD73 as a biomarker in predicting the outcome of ...suljettu
