Selaus laitoksen mukaan kokoelmassa Pro gradu -tutkielmat ja diplomityöt sekä syventävien opintojen opinnäytetyöt (rajattu näkyvyys) Biolääketieteen laitos
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[18F]FDG PET/CT imaging for evaluating associations between glycolytic activity of brown adipose tissue, breast cancer progression and cachexia in a xenograft model
(07.09.2023)BACKGROUND Brown adipose tissue (BAT) is a thermogenetic organ that helps to regulate body temperature. Besides the normal biological function of BAT, a relationship between BAT activity, cancer progression and cachexia ...suljettu -
A 3D co-culture assay to study the interaction of cancer-associated fibroblasts and immune cells in tumor microenvironment
(10.05.2024)Cancer-associated fibroblasts (CAFs) are the most prominent stromal cells of the tumor microenvironment, and their abundance has been linked to poor prognosis in several cancer types. CAFs play multiple roles in tumor ...suljettu -
A Framework for the Systematic Comparison of Classical Non-Learning, Machine Learning, and Artificial Intelligence Approaches to Cell Segmentation & Nuclei Detection in Histopathological Images
(03.08.2023)In the fields of diagnosis, digital pathology, and drug discovery, the characterization of tissue, in particular the cells, is crucial because it provides a fundamental understanding of the underlying cellular dynamics and ...suljettu -
Adipose tissue in health and disease – implications to cardiovascular diseases
(23.11.2020)Two major roles of adipose tissue are to function as a fat storage and an endocrine organ. Adipose tissue stores excess fat in adipocytes and releases when needed. Adipose tissue also secretes hormones, called adipokines, ...suljettu -
An in vitro model of hepatic steatosis and lipotoxicity – a focus on mitochondrial dysfunction and redox state
(26.05.2023)Non-alcoholic fatty liver disease (NAFLD) and alcohol-related fatty liver disease (ALD) have emerged as the leading causes of chronic liver disease worldwide. They cover a range of conditions from hepatic steatosis to ...suljettu -
Analysis of Rab24 protein expression in mouse tissues
(06.05.2020)Rab24 belongs to the Rab family of small GTPases that play important roles in intracellular vesicle formation, transportation, and fusion with target compartments. Almost 70 Rab proteins have been identified in humans so ...suljettu -
Androgen-oestrogen imbalance, obesity, and intestinal microbiota in AROM+ male mice
(17.03.2021)Androgens and oestrogens are sex hormones that produce sex-specific characteristics in males and females, respectively. However, sex hormones also possess far-reaching metabolic effects, which is evident in the comorbidity ...suljettu -
Avohoidon MRSA-tapausten epidemiologia Turun alueella vuosina 2007-2016
(01.02.2021)Tämän syventävien opintojeni kohteeksi valikoitui avohoidon MRSA-tapaukset Turussa vuosina 2007-2016. Opinnäytetyöni on osa laajempaa TY:ssa ja VSSHP:ssa käynnissä olevaa MRSA-tutkimushanketta. MRSA-infektiot aiheuttavat ...suljettu -
Blocking Clever-1 on human monocytes inhibits the growth of aggressive breast cancer
(31.07.2019)Immunosuppressive tumor microenvironment limits antitumoral immunity and facilitates cancer progression. Tumor-associated macrophages that are mainly derived from blood monocytes, are central regulators of the tumor immune ...suljettu -
Breast cancer prevention by diet : The effect of dietary polyphenols on TNF-α mediated aromatase gene (CYP19A1) expression in breast stromal cells
(24.05.2021)The different ways to prevent postmenopausal breast cancer have been under investigation for years. The effects of menopause and obesity-related adipose tissue inflammation on estrogen biosynthesis are believed to promote ...suljettu -
CD206 in colon cancer
(17.03.2020)The assessment of immunologic milieu in cancer tissue has proven to be a powerful factor in estimation of disease outcome. The basic idea is to characterize the presence of different immune cell types within tumor tissue. ...suljettu -
CD47 and TREM2 for macrophage-targeted cancer immunotherapy: Antibody validation and ex vivo efficacy in patient-derived explant cultures
(13.03.2024)Cancer remains a common cause of death worldwide. Cancer cells develop several mechanisms to escape immune destruction, which limits the efficacy of current treatments and creates a need for new therapies. Cancer immunotherapies ...suljettu -
Cell signaling in breast cancer associated with neurofibromatosis type 1
(30.04.2020)Neurofibromatosis 1 (NF1) is an autosomal dominant disorder caused by mutations in the NF1 gene, which codes tumor suppressor protein neurofibromin. The incidence of NF1 is approximately 1:2000. Patients with NF1 are at ...suljettu -
CELL-TYPE SPESIFIC CD73 EXPRESSION IS AN INDEPENDENT PROGNOSTIC FACTOR IN BLADDER CANCER
(06.11.2018)CD73 is an adenosine-producing cell surface enzyme, which exerts strong anti-inflammatory and migration modulating effects in many cell types. We evaluated the potential of CD73 as a biomarker in predicting the outcome of ...suljettu -
Changes in norepinephrine transporter expression in models of Alzheimer´s disease
(11.05.2020)Alzheimer´s disease (AD) is the most common form of dementia. AD can be associated with malfunction of the brain norepinephrine transporter (NET) and degeneration in the locus coeruleus (LC) which will reduce norepinephrine ...suljettu -
Characterization and Functional Analysis of Macrophages in Tumour-Draining Lymph Nodes
(02.05.2024)Metastasis to lymph nodes (LNs) represents a critical point in the progression of the disease, promoting spread to distant organs and systemic immunosuppression. Consequently, metastatic LNs have emerged as potential targets ...suljettu -
Characterization of glia-vascular interactions in a mitochondrial disease mouse model
(13.05.2019)Mitochondrial diseases are a cluster of genetic disorders with a profound variability of clinical symptoms, caused by mutations in mitochondrial or nuclear DNA, which lead to impairments in ATP production. The human central ...suljettu -
Characterization of Mast Cells in Human Cutaneous Neurofibromas
(03.03.2020)Neurofibromatosis type 1 (NF1) is an autosomal dominant syndrome predisposing to malignancies. Most of the adult NF1 patients exhibit cutaneous neurofibromas (cNFs) which are derived from peripheral nerves in the skin. ...suljettu -
Characterization of mice carrying Rmrp 71A>G, the causative mutation of cartilage-hair hypoplasia
(15.05.2023)Cartilage-hair hypoplasia (CHH) is a severe disease that causes short stature and abnormal immune system function and predisposes patients to many health issues, such as malignancies. There is no cure for CHH, and treatment ...suljettu -
Characterization of the novel solute carrier 26A7 gene and its impact on thyroid cell function
(10.10.2019)Thyroid hormones (THs) are essential for normal growth and development. Insufficient production of THs at birth leads to congenital hypothyroidism (CH) affecting approximately 1:3000 newborns worldwide. The etiology of CH ...suljettu
