Selaus oppiaineen mukaan kokoelmassa Pro gradu -tutkielmat ja diplomityöt sekä syventävien opintojen opinnäytetyöt (rajattu näkyvyys) Biomedical Imaging
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A Framework for the Systematic Comparison of Classical Non-Learning, Machine Learning, and Artificial Intelligence Approaches to Cell Segmentation & Nuclei Detection in Histopathological Images
(03.08.2023)In the fields of diagnosis, digital pathology, and drug discovery, the characterization of tissue, in particular the cells, is crucial because it provides a fundamental understanding of the underlying cellular dynamics and ...suljettu -
Analysis of Rab24 protein expression in mouse tissues
(06.05.2020)Rab24 belongs to the Rab family of small GTPases that play important roles in intracellular vesicle formation, transportation, and fusion with target compartments. Almost 70 Rab proteins have been identified in humans so ...suljettu -
Cross-calibration of human PET scanners with phantom studies
(31.10.2023)In the field of medical imaging currently, the speed of the technological advancements in camera design, characteristics, and performance between the Positron Emission Tomography (PET) systems varies considerably. The ...suljettu -
Effects of Nanomaterial-Delivered Protein Kinase A on Human Breast Cancer Stem Cells
(06.05.2020)The cancer stem cell (CSC) theory has been proposed as a viable explanation for the resistance of cancer cells to treatments such as radiotherapy and chemotherapy in clinical setting. Emerging studies indicate that ...suljettu -
Evaluation of Scan® 4000 Ultra-HD automatic colony counter
(13.04.2021)Enumeration of colonies manually or automatically provides a principle method for monitoring microbiological purity. Automated colony counter has potential to bring many advantages into microbiological laboratory, including ...suljettu -
Extracellular vesicles as a source for non-invasive biomarkers from human urine and serum for the early diagnosis of urological cancers
(17.08.2022)Introduction: Urological cancers-particularly cancer in prostate, bladder as well as renal organs- are one of the major causes of morbidity and mortality worldwide. Although treatment of urological cancers has expanded in ...suljettu -
Imaging and target screening for novel avenues for psychiatric disorder treatments
(18.02.2020)The JNK pathway is linked to both schizophrenia and depression but its impact is still being investigated. Zebrafish larvae at 7 days post-fertilization, were monitored for evoked motility changes after exposure to a variety ...suljettu -
Investigating filopodia formation on fibronectin and cadherin substrates
(03.08.2023)Cancer metastasis involves cancer cells migrating from primary tumours to distant organs and tissues. Filopodia, slender finger-like protrusions, play a pivotal role in cell migration and interactions with the extracellular ...suljettu -
JNK regulation of nerve cell calcium : a possible mechanism in psychiatric disease
(27.03.2019)Psychiatric disorders are a big problem in the modern world. The symptoms of these diseases vary, but common for all of them is that they are overpowering, consistent, and hamper daily life. Even though many treatments are ...suljettu -
Mechanistic study of JNK inhibition in the context of depression
(10.10.2019)Study 1: Anxiety and depression disorders are the largest contributor for global disability and affects 4% of the world population. The patient remission rate is only 30-40% with single anti-depressant treatment, leaving ...suljettu -
The effects of the combination treatment of AR and FGFR inhibitors in prostate cancer
(18.05.2021)Androgen receptor (AR) signaling is key for prostate cancer (PrCa) progression. Androgen deprivation therapy is not curative if PrCa progresses to advanced, castration-resistant PrCa and androgen-independent cancers. ...suljettu -
The Role of Arginine Vasopressin (AVP) during Birth Asphyxia
(27.08.2021)During normal vaginal birth, a surge of the stress hormone arginine vasopressin (AVP) occurs in the periphery that helps the fetus to quickly adjust to extrauterine life. During complicated birth such as mild birth asphyxia, ...suljettu -
The role of TGFβ signaling in lymphatic endothelial sprout formation
(25.11.2020)Lymphatic vasculature consists of complex treelike lymphatic vessel networks formed by lymphatic endothelial cells (LECs). The lymphatic vessel network expands via sprouting of LECs from the existing network, i.e. via ...suljettu -
The Role of Vimentin in the YAP signaling in Wound Healing and Cancer Invasion
(30.05.2023)Vimentin, a crucial cytoskeletal protein, plays a role in wound healing and cancer progression. However, its precise mechanism is not fully understood. Previous research has shown a connection between the expression ...suljettu -
Uncovering the LINC between cytoplasmic keratin 8 and nuclear lamins using 2D and 3D culture systems
(04.12.2018)Keratins are cytoplasmic intermediate filament (IF) proteins found in epithelial cells where they play a significant role in the protection from mechanical stresses. Keratin mutations have been associated with over 60 human ...suljettu -
Unraveling significance of receptor-ligand interaction on Jagged1 mobility, filopodia and ligand clustering in the Notch signaling pathway
(02.08.2019)The Notch signaling pathway plays a crucial role in many diseases. It has been proven that the Notch pathway is involved with several human cancers, including T-cell acute lymphoblastic leukemia (T-ALL) and lymphoma. It ...suljettu -
Vimentin and actin interplay in the osteoclast life cycle
(15.03.2021)Osteoclasts are large, multinucleated bone resorbing cells that partake in the process of bone remodelling, which is vital for skeletal growth, injury repair and overall bone homeostasis. They achieve their function through ...suljettu -
Visualization of cellular surface and intercellular structures of human pluripotent stem cells using electron microscopy techniques
(02.05.2022)Human Induced Pluripotent Stem Cells (hiPSCs) are a classification of stem cells that has the prospect of differentiating into any cell kind in the human body. In his lab in Kyoto, Japan, Shinya Yamanaka 2006 discovered ...suljettu