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Glycovariant Enabled Diagnosis of Renal Cell Carcinoma
Renal Cell Carcinoma (RCC) has the highest mortality rate of the genitourinary cancers. Each year, around 273, 000 new cases are diagnosed. Prognosis for patients diagnosed with RCC is dependent on the stage when it is ...
A study to discover novel biomarker glycoforms of lung cancer
Lung cancer (LuCa) is the second most common cancer among both women and men. Detection of LuCa is usually very late, at an advanced inoperable stage, for which the 5 year survival rate is only 4%. Early detection of lung ...
Design of neonatal dried blood spot immunoassays for two novel biomarkers
Spinal muscular atrophy (SMA) is a genetic disorder that leads to muscle weakness and atrophy and, in the most severe form, death before the age of two. It is caused by lack of survival of motor neuron (SMN) protein. ...
Newborn screening for spinal muscular atrophy with EnLiteTM time resolved fluorescence resonance energy transfer polymerase chain reaction
Spinal muscular atrophy (SMA) is a recessive neurodegenerative disorder, caused by mutations or a deletion in survival motor neuron (SMN) 1, the central gene for production of SMN protein. 95 % of all SMN cases are caused ...
Detection of antibodies to the hepatitis C virus using up-converting nanoparticles-based lateral flow immunoassay
Hepatitis C virus (HCV), an RNA virus, causes acute hepatitis and frequently causes chronic hepatitis, which can lead to liver cirrhosis and primary liver cancer. In 2015, the WHO reported that HCV infection globally affects ...
Part 1: The role of amyloid fibrils in protein aggregation diseases and molecular therapy. Part 2: Isolation of single-chain Fraction variable antibodies that bind to the toxic 8 kDa-fragment of gelsolin using phage display
Gelsolin amyloidosis (Meretoja’s disease) is an inherited disease with slowly developing neuromuscular symptoms. Patient’s carry a mutation leading to misfolding of the gelsolin protein, which initiates an aberrant proteolytic ...