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Aineistot 1-10 / 17
Escherichia coli ja Bacteroides vulgatus -bakteerien lipopolysakkaridien vaikutus tyypin 1 diabetekseen liittyviin autoimmuunimekanismeihin
(2022-05-19)
Tyypin 1 diabetes (T1D) on maailmanlaajuinen autoimmuunisairaus, jolle ei olla vielä keksitty parannus- tai ehkäisykeinoa. T1D vaatii jokapäiväistä verensokeriseurantaa sekä insuliinihoitoa ja voi johtaa hoitamattomana ...
Effects of parental co-exposure to heat wave and copper on zebrafish (Danio rerio) offspring thermal tolerance
(2022-06-06)
Climate change driven intensification of heat waves and increased occurrence of toxins in the aquatic environments pose a challenge for ectotherms, such as fish. Changes in the environment not only can shape the individual ...
Transgenerational effects of crude oil and heat shock on the mortality and oxygen consumption rate of Daphnia magna
(2022-07-26)
Baltic Sea is a compact area with heavy shipping activity, and since around 160 million metric tons of oil are transported annually, the risk of a major oil tanker spill is ever-present. Since climate change will raise sea ...
Evaluating computational tools for analysis of ATAC-seq data and transcription factor footprinting.
(2022-01-03)
Assay for Transposase Accessible Chromatin combined with high-throughput sequencing (ATAC-seq) is a relatively new method for inspecting the accessibility of chromatin. ATAC-seq data can be used for discovering footprints ...
Single cell RNA-seq analysis of lymphocytes from Borrelia burgdorferi infected mice
(2022-01-17)
Lyme borreliosis is a disease caused by Borrelia burgdorferi sensu lato bacteria. The symptoms of disseminated Lyme borreliosis can be nonspecific, and there is a need for specific laboratory tests. Currently, the laboratory ...
Äidin raskaudenaikaisen psykologisen stressin yhteys istukan ja napaveren glukokortikoidireseptoria koodaavan geenin DNA-metylaatioon
(2022-04-04)
Raskauden aikana n. 4–20 % naisista on havaittu kärsivän psykologisesta stressistä ja masennusoireista, jotka syntyvät erilaisten haasteiden kohtaamisesta raskauden aikana. Raskaudenaikaiset masennusoireet saattavat vaikuttaa ...
A genome-wide association study of CYP1A2 activity using tizanidine and caffeine as probe drugs
(2022-01-13)
Cytochrome P450 (CYP) enzymes are the major drug metabolizing enzyme group. The highest level of CYPs is expressed in the liver, and the human cytochrome P450 (CYP) 1A2 is one of the major CYPs playing an important role ...
Optimization of triple transfection in adeno-associated virus gene therapy vector production
(2021-02-25)
Recombinant adeno-associated virus (rAAV) is a safe gene delivery vector that provides long-term transgene expression in non-dividing somatic cells. This study was conducted to set up a large-scale rAAV vector production ...
A long-term follow-up on persistence of diarrhoeal pathogens and symptoms among Finnish travellers visiting Benin, West Africa
(2021-02-08)
Travellers’ diarrhoea is the most common health problem among visitors to tropical and subtropical areas, West Africa as one of the destinations with the highest risk. Still, the data concerning the prevalence of diarrhoeal ...
Maternaalisen hypertyreoosin pitkäaikaiset vaikutukset japaninviiriäisillä (Coturnix japonica)
(2021-08-27)
Maternaaliset kilpirauhashormonit (trijodityroniini T3 ja tyroksiini T4) ovat tärkeitä yk-silönkehityksessä. Ne säätelevät lukuisten geenien ekspressioita erityisesti keskusher-moston kehityksessä. Maternaalisten ...