Hae
Aineistot 1-10 / 11
Enzymatic Studies on the Biosynthesis of Atypical Angucycline Antibiotic Lugdunomycin in Streptomyces
(2022-08-31)
Lugdunomycin, a novel antibacterial natural product isolated from Streptomyces sp. QL37, is a highly rearranged angucycline-derived polyketide with strikingly complex structure. Its proposed biosynthetic pathway involves ...
Suupatogeenin ulkokalvon rakenteettoman lipoproteiinin ilmentyminen ja osallistuminen DNA:n sisäänottoon
(2022-06-20)
Aggregatibacter actinomycetemcomitans on gram-negatiivinen, opportunistinen suupatogeeni, joka kasvaa hampaan pinnalla biofilminä aiheuttaen kroonista tulehdusta, parodontiittia. A. actinomycetemcomitansin patogeenisuus ...
Non-genetic rewiring of ERBB signaling in cancer drug tolerance
(2022-05-11)
ERBB receptors are transmembrane receptor tyrosine kinases (RTKs) that are activated by dimerization and intracellular tyrosine phosphorylation upon ligand binding. The ERBB family includes EGFR, ERBB2, ERBB3, and ERBB4 ...
Akkermansia muciniphilan ja Citrobacter rodentiumin vastakkaiset vaikutukset autoimmuunidiabeteksen kehittymiseen NOD-hiirellä
(2022-05-11)
Tyypin 1 diabeteksessa haiman Langerhansin saarekkeiden insuliinia tuottavat betasolut
tuhoutuvat autoimmuunireaktiossa, jolloin glukoositasapainon ylläpito estyy. Antigeeniä
esittelevät solut (APC, antigen presenting ...
Non-invasiivisen prenataaliseulonnan toiminnallisuuden kehittäminen
(2022-06-08)
Sikiön kehityksen aikana kromosomisto voi kehittyä virheellisesti, joka johtaa poikkeavaan kromosomimäärään. Poikkeavuudet aiheuttavat sikiölle ominaisuuksia, joista osa voi olla sikiölle hengenvaarallisia. Tässä työssä ...
Long-acting silica formulations - In vitro study of inflammatory response in the eye
(2021-10-18)
Inflammation is body’s typical response to unnatural, pathogenic events occurring inside the individual. In the eye, inflammation is a critical condition which can lead to sever problems, including permanent loss of vision. ...
Silicone microparticles for drug delivery applications
(2021-05-25)
Drug delivery systems aim to provide safe and efficient delivery of drugs. One category of drug delivery systems is microparticles which have versatile properties. Large surface to volume ratio enhances solubility of loaded ...
DUSP1 and DUSP6 : The novel therapeutic targets in drug-resistant HER2+ breast cancer
(2021-03-25)
The human epidermal growth factor receptor 2 (HER2) is overexpressed and/or amplified in 15-20% of breast cancer patients and associates with a poor survival. Most patients with HER2+ breast cancer develop resistance to ...
The impact of HSF1 or HSF2 knockdown on HSP90 inhibitor sensitivity in mammalian cells
(2023-03-06)
The heat shock response (HSR) induces the expression of the heat shock protein 90 (HSP90). HSP90 also maintains protein homeostasis by acting as a molecular chaperone. However, HSP90 is also known to be associated with ...
Oligonukleotidiraaka-aineen puhtauden optimointi Vanadis NIPT Assay analyysille
(2023-03-23)
Kromosomaalisten sairauksien seulonta on osa kansallisia raskaudenaikaisia tutkimuksia. Seulontojen tarkoitus on tunnistaa kromosomipoikkeavuudet sikiönkehityksen alkuvaiheessa, ja siten helpottaa hoitopäätösten tekoa. ...