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Effects of Nanomaterial-Delivered Protein Kinase A on Human Breast Cancer Stem Cells
(2020-05-06)
The cancer stem cell (CSC) theory has been proposed as a viable explanation for the resistance of cancer cells to treatments such as radiotherapy and chemotherapy in clinical setting. Emerging studies indicate that ...
Changes in norepinephrine transporter expression in models of Alzheimer´s disease
(2020-05-11)
Alzheimer´s disease (AD) is the most common form of dementia. AD can be associated with malfunction of the brain norepinephrine transporter (NET) and degeneration in the locus coeruleus (LC) which will reduce norepinephrine ...
Cell signaling in breast cancer associated with neurofibromatosis type 1
(2020-04-30)
Neurofibromatosis 1 (NF1) is an autosomal dominant disorder caused by mutations in the NF1 gene, which codes tumor suppressor protein neurofibromin. The incidence of NF1 is approximately 1:2000. Patients with NF1 are at ...
Intracellular metabolism and transport of paclitaxel in ovarian cancer
(2020-04-30)
Although traditional chemotherapies are still the backbone of ovarian cancer treatment, interpatient variability in drug response and acquired resistance still present a major hurdle. The antimitotic agent, paclitaxel, is ...
Targeting JNKs with systemic viruses towards a mechanistic understanding of anxiety-like behaviour
(2022-09-05)
Depression and anxiety disorders are one of the most common mental health conditions. To develop better treatments for the disorders, it is necessary to understand their mechanisms better. Genetic aberrations on the c-Jun ...
Spatial Engineering of Human Breast Tissue Cultures by 3D Bioprinting
(2022-08-29)
Extracellular matrix (ECM) is an integral part of breast tissue microenvironment, and it plays important roles in mammary gland development and homeostasis as well as in breast cancer progression. However, the in vivo ...
Extracellular vesicles as a source for non-invasive biomarkers from human urine and serum for the early diagnosis of urological cancers
(2022-08-17)
Introduction: Urological cancers-particularly cancer in prostate, bladder as well as renal organs- are one of the major causes of morbidity and mortality worldwide. Although treatment of urological cancers has expanded in ...
The role of bacterial lipopolysaccharides and gut microbiota dysbiosis in type 1 diabetes
(2022-10-10)
The definitive etiology of type 1 diabetes (T1D) remains uncertain. However, various studies suggest that gut microbiota dysbiosis might contribute to the development of islet autoimmunity. This risk could be mediated by ...
Contribution of BIM Serine 87 phosphorylation on targeted therapy response
(2022-06-06)
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are the standard-of-care for the treatment of EGFR-mutant non-small cell lung cancer (NSCLC) with typically excellent response rates. However, no ...
Visualization of cellular surface and intercellular structures of human pluripotent stem cells using electron microscopy techniques
(2022-05-02)
Human Induced Pluripotent Stem Cells (hiPSCs) are a classification of stem cells that has the prospect of differentiating into any cell kind in the human body. In his lab in Kyoto, Japan, Shinya Yamanaka 2006 discovered ...