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Spatial Engineering of Human Breast Tissue Cultures by 3D Bioprinting
(2022-08-29)
Extracellular matrix (ECM) is an integral part of breast tissue microenvironment, and it plays important roles in mammary gland development and homeostasis as well as in breast cancer progression. However, the in vivo ...
The role of bacterial lipopolysaccharides and gut microbiota dysbiosis in type 1 diabetes
(2022-10-10)
The definitive etiology of type 1 diabetes (T1D) remains uncertain. However, various studies suggest that gut microbiota dysbiosis might contribute to the development of islet autoimmunity. This risk could be mediated by ...
Contribution of BIM Serine 87 phosphorylation on targeted therapy response
(2022-06-06)
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are the standard-of-care for the treatment of EGFR-mutant non-small cell lung cancer (NSCLC) with typically excellent response rates. However, no ...
Microbiota-derived extracellular vesicles cargo composition analysis using hTLR cell lines
(2022-03-28)
Bacterial cells interact with other bacteria and their host cells via direct interaction or the secretion of soluble components, such bacterial extracellular vesicles (BEVs). BEVs distribute a portion of the parent bacterium ...
SHANK-regulation of drug sensitivity in KRAS-driven cancer
(2022-05-02)
Ras proteins are intracellular GTPase switch proteins activating MAPK/ERK signaling pathways in their active GTP-bound forms. Mutant KRAS oncoproteins are mostly in their active state, fostering ERK-dependent cell proliferation ...
Optimisation of adeno-associated viral vector production using Design of Experiments
(2022-04-29)
Adeno-associated virus (AAV) vectors are widely used in in vivo gene therapy. The increasing popularity leads to demand for higher manufacturing capacities. The yield achieved with the most common production method, triple ...
Somatostatin neurons in the ventral tegmental area; addiction- and anxiety-related behaviours in mice
(2020-10-16)
Ventral tegmental area (VTA) with diverse cell populations is associated with reward, aversion and motivation. Somatostatin is an endogenous peptide with wide range of physiological functions, which are mediated through ...
Characterization of glia-vascular interactions in a mitochondrial disease mouse model
(2019-05-13)
Mitochondrial diseases are a cluster of genetic disorders with a profound variability of clinical symptoms, caused by mutations in mitochondrial or nuclear DNA, which lead to impairments in ATP production. The human central ...
Functional Characterization of NF1 Deficient Breast Cancer
(2020-11-16)
Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with an incidence of 1:2,000. NF1 is caused by pathogenic variants of the tumor suppressor gene NF1. The NF1 syndrome increases cancer incidence and is ...
Validation of UBR5 as a novel PIM kinase substrate
(2020-10-21)
The serine/threonine-specific PIM kinases have important roles in regulation of cell proliferation, survival, and motility. UBR5 is an E3 ubiquitin ligase and is involved in the regulation of gene expression, apoptosis, ...