Hae
Aineistot 11-20 / 30
Evaluating computational tools for analysis of ATAC-seq data and transcription factor footprinting.
(2022-01-03)
Assay for Transposase Accessible Chromatin combined with high-throughput sequencing (ATAC-seq) is a relatively new method for inspecting the accessibility of chromatin. ATAC-seq data can be used for discovering footprints ...
Single cell RNA-seq analysis of lymphocytes from Borrelia burgdorferi infected mice
(2022-01-17)
Lyme borreliosis is a disease caused by Borrelia burgdorferi sensu lato bacteria. The symptoms of disseminated Lyme borreliosis can be nonspecific, and there is a need for specific laboratory tests. Currently, the laboratory ...
Äidin raskaudenaikaisen psykologisen stressin yhteys istukan ja napaveren glukokortikoidireseptoria koodaavan geenin DNA-metylaatioon
(2022-04-04)
Raskauden aikana n. 4–20 % naisista on havaittu kärsivän psykologisesta stressistä ja masennusoireista, jotka syntyvät erilaisten haasteiden kohtaamisesta raskauden aikana. Raskaudenaikaiset masennusoireet saattavat vaikuttaa ...
A genome-wide association study of CYP1A2 activity using tizanidine and caffeine as probe drugs
(2022-01-13)
Cytochrome P450 (CYP) enzymes are the major drug metabolizing enzyme group. The highest level of CYPs is expressed in the liver, and the human cytochrome P450 (CYP) 1A2 is one of the major CYPs playing an important role ...
Delivery of Cas9/sgRNA system using functionalized mesoporous silica nanoparticle system
(2020-09-03)
CRISPR/Cas9 has become an attractive tool for performing genomic editing due to its versatility and efficiency. However, one of the major challenges in CRISPR/Cas9-based genome editing is the active delivery to the specific ...
Onkolyyttisen, dekoriinia ilmentävän herpesvirusvektorin kehittäminen
(2020-03-26)
Geeniterapialla pyritään hoitamaan sairauksia tai estämään sairauden puhkeaminen siirtämällä terapeuttinen geeni potilaaseen. Siirtogeenin saamiseksi kohdesoluihin tarvitaan vektoreita kuljettimiksi, joihin virukset sopivat ...
Specific Targeting and Novel Molecular Players in Leukemogenesis Associated with Mutant Nucleophosmin
(2020-05-25)
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. In AML, NPM (nucleophosmin) is the most frequently mutated gene. NPM is a nucleolar shuttling protein that interacts with several proteins, and ...
Glyfosaattialtistuksen (Roundup® Flex) vaikutukset japaninviiriäisten (Coturnix japonica) maksaan ja alkioihin
(2019-04-18)
Glyfosaatti on rikkakasvien torjuntaan eniten käytetty tehoaine maailmanlaajuisesti. Glyfosaatin tunnetuin kauppanimi on Roundup, joka on laajakirjoinen ja epäselektiivinen rikkakasvien torjunta-aine. Glyfosaatin käyttö ...
Ex vivo assessment of efficacy of targeted therapies for treatment of HER2-positive parotid gland cancer
(2019-04-09)
HER2 (human epidermal growth factor receptor 2) positive salivary gland carcinomas are extremely rare with incidence lower than 1 % of all cancers worldwide. Unlike other salivary gland neoplasms, HER2+ salivary gland ...
Effects of exercise on heart function and tumor growth in mice with melanoma
(2019-07-31)
Millions of people are diagnosed with cancer every year. Many cancers are known to induce muscle wasting called cachexia. Cancer cachexia can lead to cardiac atrophy and disrupted cardiac function.
Exercise has previously ...