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Microbiota-derived extracellular vesicles cargo composition analysis using hTLR cell lines
(2022-03-28)
Bacterial cells interact with other bacteria and their host cells via direct interaction or the secretion of soluble components, such bacterial extracellular vesicles (BEVs). BEVs distribute a portion of the parent bacterium ...
SHANK-regulation of drug sensitivity in KRAS-driven cancer
(2022-05-02)
Ras proteins are intracellular GTPase switch proteins activating MAPK/ERK signaling pathways in their active GTP-bound forms. Mutant KRAS oncoproteins are mostly in their active state, fostering ERK-dependent cell proliferation ...
Optimisation of adeno-associated viral vector production using Design of Experiments
(2022-04-29)
Adeno-associated virus (AAV) vectors are widely used in in vivo gene therapy. The increasing popularity leads to demand for higher manufacturing capacities. The yield achieved with the most common production method, triple ...
Somatostatin neurons in the ventral tegmental area; addiction- and anxiety-related behaviours in mice
(2020-10-16)
Ventral tegmental area (VTA) with diverse cell populations is associated with reward, aversion and motivation. Somatostatin is an endogenous peptide with wide range of physiological functions, which are mediated through ...
Characterization of glia-vascular interactions in a mitochondrial disease mouse model
(2019-05-13)
Mitochondrial diseases are a cluster of genetic disorders with a profound variability of clinical symptoms, caused by mutations in mitochondrial or nuclear DNA, which lead to impairments in ATP production. The human central ...
Functional Characterization of NF1 Deficient Breast Cancer
(2020-11-16)
Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with an incidence of 1:2,000. NF1 is caused by pathogenic variants of the tumor suppressor gene NF1. The NF1 syndrome increases cancer incidence and is ...
Validation of UBR5 as a novel PIM kinase substrate
(2020-10-21)
The serine/threonine-specific PIM kinases have important roles in regulation of cell proliferation, survival, and motility. UBR5 is an E3 ubiquitin ligase and is involved in the regulation of gene expression, apoptosis, ...
Identifying the issues concerning zeta potential measurements of polymer nanoparticles
(2019-05-13)
Introduction:
Recent polymeric nanoparticle appraisals, formulation and drug delivery strategies have been showed up with remarkable advancement although scientists are still looking forward to better targeted drug ...
Adipose tissue in health and disease – implications to cardiovascular diseases
(2020-11-23)
Two major roles of adipose tissue are to function as a fat storage and an endocrine organ. Adipose tissue stores excess fat in adipocytes and releases when needed. Adipose tissue also secretes hormones, called adipokines, ...
Development of in vitro test battery to predict toxicity of indoor air
(2019-05-02)
The impurities of the air inside the buildings and the resulting health issues have become an increasing problem. Impurities of indoor air may cause various symptoms, such as respiratory symptoms, nausea, fatigue and memory ...