Hae
Aineistot 31-40 / 107
The role of bacterial lipopolysaccharides and gut microbiota dysbiosis in type 1 diabetes
(2022-10-10)
The definitive etiology of type 1 diabetes (T1D) remains uncertain. However, various studies suggest that gut microbiota dysbiosis might contribute to the development of islet autoimmunity. This risk could be mediated by ...
Contribution of BIM Serine 87 phosphorylation on targeted therapy response
(2022-06-06)
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are the standard-of-care for the treatment of EGFR-mutant non-small cell lung cancer (NSCLC) with typically excellent response rates. However, no ...
Visualization of cellular surface and intercellular structures of human pluripotent stem cells using electron microscopy techniques
(2022-05-02)
Human Induced Pluripotent Stem Cells (hiPSCs) are a classification of stem cells that has the prospect of differentiating into any cell kind in the human body. In his lab in Kyoto, Japan, Shinya Yamanaka 2006 discovered ...
Searching for activating ERBB2 mutations with a high throughput screen
(2021-12-03)
There are numerous reports of ERBB mutations in various cancer types. Majority of the identified cancer-associated mutations usually accumulate in certain functional areas of these genes, called hotspots, and the frequency ...
Exploring minimally invasive approach to define stages of type 1 diabetes remotely
(2022-07-06)
The purpose of this study was to study the use of continuous glucose monitoring (CGM) in children who have a high lifetime genetic risk for developing type 1 diabetes. We wanted to find out if the different stages of type ...
Synnynnäiset aivojen rakennepoikkeavuudet ja niiden fenotyypit Varsinais-Suomessa
(2022-03-22)
Synnynnäiset aivojen rakennepoikkeavuudet ovat oirekuviltaan ja aiheuttajiltaan heterogeeninen
ryhmä, joista on verrattain vähän laajaa aiempaa Suomessa tehtyä tutkimustietoa. Tämän tutkimuksen
tavoitteena oli lisätä ...
Microbiota-derived extracellular vesicles cargo composition analysis using hTLR cell lines
(2022-03-28)
Bacterial cells interact with other bacteria and their host cells via direct interaction or the secretion of soluble components, such bacterial extracellular vesicles (BEVs). BEVs distribute a portion of the parent bacterium ...
Transcriptomic and functional analysis of EWSR1-CREM fusion oncogene in melanoma cell line CHL-1
(2022-03-29)
Fusion genes bearing EWSR1-CREB have been reported in several neoplasms of variating origin, also in melanoma. However, not many have concentrated on the functional role of EWSR1-CREB family fusions in vitro. Less studied ...
SHANK-regulation of drug sensitivity in KRAS-driven cancer
(2022-05-02)
Ras proteins are intracellular GTPase switch proteins activating MAPK/ERK signaling pathways in their active GTP-bound forms. Mutant KRAS oncoproteins are mostly in their active state, fostering ERK-dependent cell proliferation ...
Optimisation of adeno-associated viral vector production using Design of Experiments
(2022-04-29)
Adeno-associated virus (AAV) vectors are widely used in in vivo gene therapy. The increasing popularity leads to demand for higher manufacturing capacities. The yield achieved with the most common production method, triple ...