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Somatostatin neurons in the ventral tegmental area; addiction- and anxiety-related behaviours in mice
(2020-10-16)
Ventral tegmental area (VTA) with diverse cell populations is associated with reward, aversion and motivation. Somatostatin is an endogenous peptide with wide range of physiological functions, which are mediated through ...
Characterization of glia-vascular interactions in a mitochondrial disease mouse model
(2019-05-13)
Mitochondrial diseases are a cluster of genetic disorders with a profound variability of clinical symptoms, caused by mutations in mitochondrial or nuclear DNA, which lead to impairments in ATP production. The human central ...
Functional Characterization of NF1 Deficient Breast Cancer
(2020-11-16)
Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with an incidence of 1:2,000. NF1 is caused by pathogenic variants of the tumor suppressor gene NF1. The NF1 syndrome increases cancer incidence and is ...
Validation of UBR5 as a novel PIM kinase substrate
(2020-10-21)
The serine/threonine-specific PIM kinases have important roles in regulation of cell proliferation, survival, and motility. UBR5 is an E3 ubiquitin ligase and is involved in the regulation of gene expression, apoptosis, ...
Identifying the issues concerning zeta potential measurements of polymer nanoparticles
(2019-05-13)
Introduction:
Recent polymeric nanoparticle appraisals, formulation and drug delivery strategies have been showed up with remarkable advancement although scientists are still looking forward to better targeted drug ...
Adipose tissue in health and disease – implications to cardiovascular diseases
(2020-11-23)
Two major roles of adipose tissue are to function as a fat storage and an endocrine organ. Adipose tissue stores excess fat in adipocytes and releases when needed. Adipose tissue also secretes hormones, called adipokines, ...
Development of in vitro test battery to predict toxicity of indoor air
(2019-05-02)
The impurities of the air inside the buildings and the resulting health issues have become an increasing problem. Impurities of indoor air may cause various symptoms, such as respiratory symptoms, nausea, fatigue and memory ...
Dietary Intake in Relation to the Risk of Developing Gestational Diabetes
(2020-04-17)
BACKGROUND Gestational diabetes (GDM) may predispose both the mother and her child to unfavorable health effects. Previous studies indicate that early pregnancy diet could explain the development of GDM in late pregnancy, ...
In vitro evaluation of nanoantibiotics
(2020-04-15)
The discovery of antibiotics made a significant difference in human mortality by considerably reducing the number of deaths caused by infections. Over the years, the bacteria gradually developed resistance against available ...
CD206 in colon cancer
(2020-03-17)
The assessment of immunologic milieu in cancer tissue has proven to be a powerful factor in estimation of disease outcome. The basic idea is to characterize the presence of different immune cell types within tumor tissue. ...