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Aineistot 21-40 / 226

    • Bone Health, Osteoporosis and Fracture Risk in Neurofibromatosis 1 - An Emphasis on Osteoclasts 

      Heervä, Eetu
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1013 (Turun yliopisto, 29.06.2012)
      Neurofibromatosis 1 (NF1) is an autosomal dominant hereditary syndrome, affecting skin, neural tissues and skeleton. Hallmarks of NF1 include benign cutaneous neurofibroma tumors, pigmentation lesions on the skin and in ...

    • Calcium signaling and neuropeptide Y in experimental models of heart failure 

      Mattila, Minttu
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica-Odontologica : 1508 (Turun yliopisto, 13.11.2020)
      Despite advances in medical therapy and interventional procedures, heart failure carries a dismal prognosis. Calcium has a central role in controlling the contractility of the heart, and the sarcoplasmic reticulum Ca2+ ...

    • Cavity-based negative images in molecular docking 

      Kurkinen, Sami
      Turun yliopiston julkaisua -Annales Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1577 (Turun yliopisto, 01.10.2021)
      In drug development, computer-based methods are constantly evolving as a result of increasing computing power and cumulative costs of generating new pharmaceuticals. With virtual screening (VS), it is possible to screen ...

    • CD73 in triple-negative breast cancer 

      Petruk, Nataliia
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis D: Medica - Odontologica : 1761 (Turun yliopisto, 16.12.2023)
      CD73 is a membrane-bound receptor that converts AMP to adenosine. Its overexpression in tumors is associated with poor outcomes in triple-negative breast cancer (TNBC) patients. TNBC patients have limited treatment options ...

    • Cell surface interactions of coxsackievirus A9 and human parechovirus 1 

      Merilahti, Pirjo
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1283 (Turun yliopisto, 12.05.2017)
      Coxsackievirus A9 (CV-A9) and human parechovirus 1 (HPeV-1) belong to family Picornaviridae, genera Enterovirus and Parechovirus respectively. CV-A9 has been associated with aseptic meningitis, myocarditis in addition to ...

    • Cellular regulation of the norepinephrine transporter 

      Vuorenpää, Anne
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1336 (Turun yliopisto, 23.02.2018)
      The norepinephrine (NE) transporter (NET) mediates high-affinity uptake of the neurotransmitter NE in central and peripheral noradrenergic neurons. NET has a critical function in controlling the synaptic levels of NE and ...

    • Cellular vulnerabilities of glioblastoma 

      Merisaari, Joni
      Turun yliopiston julkaisua -Annales Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1568 (Turun yliopisto, 15.10.2021)
      Glioblastoma (GB) is the most fatal and frequent malignant brain tumor, and it is driven by multiple oncogenic pathways. Despite intensive screening of genomic, transcriptomic, metabolic, and post-translational landscape ...

    • Characteristics of anti-pertussis toxin antibodies after vaccination and infection 

      Knuutila, Aapo
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis D: Medica - Odontologica : 1780 (Turun yliopisto, 12.04.2024)
      Pertussis or whooping cough is a human respiratory tract infection caused by Bordetella pertussis bacteria. Despite extensive vaccinations, pertussis incidence has increased during the last decades. The reasons behind this ...

    • Characterization of Gamma-Secretase-Mediated Cleavage of Receptor Tyrosine Kinases 

      Merilahti, Johannes
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1558 (Turun yliopisto, 10.09.2021)
      ABSTRACT Receptor tyrosine kinases (RTK) are a family of cell surface receptors consisting of 55 members. RTKs regulate intracellular signaling pathways that control fundamental cellular processes including differentiation, ...

    • Characterization of novel genes predominantly expressed in the epididymis – from genome analyses to genetically modified mice 

      Turunen, Heikki
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 992 (Turun yliopisto, 18.11.2011)
      In mammals, post-testicular sperm maturation taking place in the epididymis is required for the spermatozoa to acquire the abilities required to fertilize the egg <i>in vivo</i>. The epididymal epithelial cells secrete ...

    • Chromatoid body mediated RNA regulation in mouse male germline 

      Meikar, Oliver
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1099 (Turun yliopisto, 20.12.2013)
      Male germ cell differentiation, spermatogenesis is an exceptional developmental process that produces a massive amount of genetically unique spermatozoa. The complexity of this process along with the technical limitations ...

    • CIP2A is a critical DNA damage response protein that drives basal-like breast cancer 

      Nagelli, Srikar
      Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odontologica : 1699 (Turun yliopisto, 14.04.2023)
      Basal-like breast cancer (BLBC) is an aggressive and therapeutically most challenging breast cancer subtype, due to a lack of druggable breast specific surface receptors (ER, PR, HER2) or driver mechanisms. BLBC patients ...

    • Clinical studies on testicular growth and descent 

      Koskenniemi, Jaakko
      Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1334 (Turun yliopisto, 02.02.2018)
      Recent population-based cohort studies indicate that semen quality is declining and simultaneously the incidence of testicular germ-cell cancer is increasing globally. A failure of testicular descent i.e. cryptorchidism ...

    • Convergence of RAS and PP2A activities on chromatin repressor complexes 

      Sharma, Mukund
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis D: Medica - Odontologica : 1778 (Turun yliopisto, 22.03.2024)
      Protein Phosphatase 2A (PP2A) is a serine-threonine phosphatase and, through its de-phosphorylation activity, mostly downregulates signaling pathways, while RAS belongs to the family of small GTPase and activates various ...

    • COVID-19 vaccine-induced adaptive immunity against SARS-CoV-2 variants 

      Jalkanen, Pinja
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1746 (Turun yliopisto, 27.10.2023)
      The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has necessitated the rapid development and deployment of vaccines worldwide. mRNA-based vaccines ...

    • Crosstalk between cell adhesion and the actin cytoskeleton 

      Salomaa, Siiri
      Turun yliopiston julkaisua -Annales Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1501 (Turun yliopisto, 25.09.2020)
      In order to form tissues and to move, cells need to attach to the surrounding environment. Integrins are the major cell adhesion receptors that cells use to attach to the extracellular matrix on the outside of the cell, ...

    • Data-independent acquisition mass spectrometry for human gut microbiota metaproteome analysis 

      Pietilä, Sami
      Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odontologica : 1603 (Turun yliopisto, 13.01.2022)
      Human digestive tract microbiota is a diverse community of microorganisms having complex interactions between microbes and the human host. Observing the functions carried out by microbes is essential for gaining understanding ...

    • Detection, Identification and Molecular Variation of Human Enteroviruses 

      Österback, Riikka
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1201 (Turun yliopisto, 28.11.2015)
      Picornaviruses are the most common human viruses and the identification of the picornaviruses is nowadays based on molecular techniques, for example, reverse transcriptase polymerase ...

    • Development of male reproductive health in puberty and young adulthood 

      Sadov, Sergey
      Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1395 (Turun yliopisto, 30.11.2018)
      The deterioration of male reproductive health is a worrying global trend in respect to the individual fertility of the man. Modern knowledge suggests the etiological role for early testicular damage and harmful effects of ...

    • Developmental aspects of male reproductive health: clinical studies on semen quality, cryptorchidism, and puberty 

      Rodprasert, Wiwat
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica-Odontologica : 1729 (Turun yliopisto, 11.08.2023)
      Current evidence shows increasing rates of male reproductive disorders, including cryptorchidism, hypospadias, poor semen quality, decreased testosterone level, and testicular cancer. Therefore, studies on the physiology ...