• A Farewell to Flat Biology. Three-dimensional Cell Culture Models in Cancer Drug Target Identification and Validation 

      Härmä, Ville
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1028 (Turun yliopisto, 14.09.2012)
      Cells of epithelial origin, e.g. from breast and prostate cancers, effectively differentiate into complex multicellular structures when cultured in three-dimensions (3D) instead of conventional two-dimensional (2D) adherent ...
    • A Systems Biology Analysis of PP2A Functions in Cancer Cells 

      Kauko, Otto
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1264 (Turun yliopisto, 20.01.2017)
      Cancer is characterized by aberrant activation of phosphorylation signalling cascades. However, despite the critical role of phosphatases in protein phosphorylation, their contribution to cancer cell signalling is only ...
    • Alpha- and gamma-melanocyte stimulating hormones in obesity. A study of the key central areas of metabolic regulation 

      Eerola, Kim
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1128 (Turun yliopisto, 19.09.2014)
      The melanocortin system is an important regulator of feeding, energy metabolism,and cardiovascular function and it consists of the pro-opiomelanocortin (POMC) derived melanocyte stimulating hormones (α-, β- and γ-MSH) and ...
    • Alpha2-Adrenoceptor-mediated vascular responses induced by dexmedetomidine 

      Posti, Jussi P.
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1017 (Turun yliopisto, 15.06.2012)
      Alpha2-Adrenoceptors are cell-surface G protein coupled receptors that mediate many of the effects of the catecholamines noradrenaline and adrenaline. The three human α2-adrenoceptor subtypes are widely expressed in different ...
    • Analyzing change in medication use - statistical approaches 

      Lavikainen, Piia
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1241 (Turun yliopisto, 12.08.2016)
      The objective of this study was to gain an understanding of the effects of population heterogeneity, missing data, and causal relationships on parameter estimates from statistical models when analyzing change ...
    • ANDROGEN SIGNALING AXIS AS DRUG TARGET IN CASTRATION-RESISTANT PROSTATE CANCER: Preclinical development of novel treatments and models 

      Oksala, Riikka
      Turun yliopiston julkaisuja. Sarja D, Medica - Odontologica : 1364 (Turun yliopisto, 15.06.2018)
      Abstract: Prostate cancer is a major global challenge due to the increasing number of aging population and frequency of diagnosis. Already in 1941, Huggins and Hodges showed that metastatic prostate cancer is responsive ...
    • Application of RNAi to silence tartrate-resistant acid phosphatase: unexpected effects on the monocyte-macrophage lineage 

      Muhonen, Pirkko
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 766 (Turun yliopisto, 02.11.2007)
      <b>Tartraatti-resistentin happaman fosfataasin hiljentäminen RNAi menetelmällä: odottamaton vaikutus monosyytti-makrofagi linjan soluissa</b> RNA interferenssi (RNAi) eli RNA:n hiljentyminen löydettiin ensimmäisenä ...
    • Assay development and study of a mutation affecting gonadotropin action 

      Trehan, Ashutosh
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1246 (Turun yliopisto, 23.09.2016)
      The gonadotropin action mediated via three glycoprotein hormones, luteinizing hormone (LH), chorionic gonadotropin (CG) and follicle-stimulating hormone (FSH) is paramount for sexual differentiation, pubertal development ...
    • Bioimage informatics in STED super-resolution microscopy 

      Koho, Sami
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1219 (Turun yliopisto, 04.03.2016)
      Optical microscopy is living its renaissance. The diffraction limit, although still physically true, plays a minor role in the achievable resolution in far-field fluorescence microscopy. Super-resolution ...
    • Biosynthesis of Yersinia enterocolitica serotype O:3 lipopolysaccharide outer core 

      Pinta, Elise
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 927 (Turun yliopisto, 19.11.2010)
      Lipopolysacharide (LPS) present on the outer leaflet of Gram-negative bacteria is important for the adaptation of the bacteria to the environment. Structurally, LPS can be divided into three parts: lipid A, core and ...
    • Bone Health, Osteoporosis and Fracture Risk in Neurofibromatosis 1 - An Emphasis on Osteoclasts 

      Heervä, Eetu
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1013 (Turun yliopisto, 29.06.2012)
      Neurofibromatosis 1 (NF1) is an autosomal dominant hereditary syndrome, affecting skin, neural tissues and skeleton. Hallmarks of NF1 include benign cutaneous neurofibroma tumors, pigmentation lesions on the skin and in ...
    • Cell surface interactions of coxsackievirus A9 and human parechovirus 1 

      Merilahti, Pirjo
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1283 (Turun yliopisto, 12.05.2017)
      Coxsackievirus A9 (CV-A9) and human parechovirus 1 (HPeV-1) belong to family Picornaviridae, genera Enterovirus and Parechovirus respectively. CV-A9 has been associated with aseptic meningitis, myocarditis in addition to ...
    • Cellular regulation of the norepinephrine transporter 

      Vuorenpää, Anne
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1336 (Turun yliopisto, 23.02.2018)
      The norepinephrine (NE) transporter (NET) mediates high-affinity uptake of the neurotransmitter NE in central and peripheral noradrenergic neurons. NET has a critical function in controlling the synaptic levels of NE and ...
    • Characterization of novel genes predominantly expressed in the epididymis – from genome analyses to genetically modified mice 

      Turunen, Heikki
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 992 (Turun yliopisto, 18.11.2011)
      In mammals, post-testicular sperm maturation taking place in the epididymis is required for the spermatozoa to acquire the abilities required to fertilize the egg <i>in vivo</i>. The epididymal epithelial cells secrete ...
    • Chromatoid body mediated RNA regulation in mouse male germline 

      Meikar, Oliver
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1099 (Turun yliopisto, 20.12.2013)
      Male germ cell differentiation, spermatogenesis is an exceptional developmental process that produces a massive amount of genetically unique spermatozoa. The complexity of this process along with the technical limitations ...
    • Clinical studies on testicular growth and descent 

      Koskenniemi, Jaakko
      Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1334 (Turun yliopisto, 02.02.2018)
      Recent population-based cohort studies indicate that semen quality is declining and simultaneously the incidence of testicular germ-cell cancer is increasing globally. A failure of testicular descent i.e. cryptorchidism ...
    • Detection, Identification and Molecular Variation of Human Enteroviruses 

      Österback, Riikka
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1201 (Turun yliopisto, 28.11.2015)
      Picornaviruses are the most common human viruses and the identification of the picornaviruses is nowadays based on molecular techniques, for example, reverse transcriptase polymerase ...
    • Development of male reproductive health in puberty and young adulthood 

      Sadov, Sergey
      Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1395 (Turun yliopisto, 30.11.2018)
      The deterioration of male reproductive health is a worrying global trend in respect to the individual fertility of the man. Modern knowledge suggests the etiological role for early testicular damage and harmful effects of ...
    • Diet, microbes and gut immune responses in the pathogenesis of experimental type 1 diabetes 

      Emani, Rohini
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1242 (Turun yliopisto, 09.09.2016)
      Type 1diabetes (T1D) is an autoimmune disease, which is influenced by a variety of environmental factors including diet and microbes. These factors affect the homeostasis and the immune system of ...
    • Diffusion Tensor Imaging as a Diagnostic and Research Tool: A Study on Preterm Infants 

      Saunavaara, Virva
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1096 (Turun yliopisto, 17.01.2014)
      Diffusion tensor imaging (DTI) is an advanced magnetic resonance imaging (MRI) technique. DTI is based on free thermal motion (diffusion) of water molecules. The properties of diffusion can be represented using parameters ...