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Advancing antibody engineering: Development of a novel Bxb1 landing pad-based mammalian display platform for the selection of biophysically favorable antibodies
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis F: Technica & Informatica : 48 (Turun yliopisto, 13.12.2024)Owing to their high clinical success rate, advancements in biotechnology, and increased understanding of disease mechanisms, therapeutic antibodies have become an important modality for the treatment of many diseases. ... -
Cardiac Troponin Specific Autoantibodies: Analytical Tools for Exploring Their Impact on Cardiac Troponin I Testing
Turun yliopiston julkaisuja. Sarja AII, Biologica - Geographica – Geologica : 293 (Turun yliopisto, 17.10.2014)Cardiac troponin (cTn) I and T are the recommended biomarkers for the diagnosis and risk stratification of patients with suspected acute coronary syndrome (ACS), a major cause of cardiovascular death and disability worldwide. ... -
Diagnostic and prognostic value of free PAPP-A in coronary artery disease – clinical studies with novel immunoassay
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser F: Informatica & Technologica : 17 (Turun yliopisto, 09.12.2022)Complications of coronary artery disease are the number one cause of death worldwide, so identification of high-risk individuals is crucial. Pregnancy-associated plasma protein A (PAPP-A) is a candidate cardiac-risk related ... -
Novel circulatory biomarkers for ovarian cancer diagnosis: Nanoparticle based glycovariant assays
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis F: Technica & Informatica : 49 (Turun yliopisto, 05.12.2024)Ovarian cancer is the most lethal gynecological malignancy and the seventh most common cancer worldwide. Current diagnosis options for ovarian cancer suffer from a lack of sensitivity and specificity that lead to either ... -
Phage display based approach for identifying novel HDL particle binders: Recombinant HDL antibodies as novel diagnostic tool for risk assessment and monitoring of coronary artery disease
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser A I: Astronomica, Chemica, Mathematica : 678 (Turun yliopisto, 11.11.2022)Cholesterol content of high density lipoprotein (HDL-C) has been a well established cardiac risk marker for coronary artery disease (CAD), a major cause of mortality worldwide. Various epidemiological and experimental ... -
Upconverting nanoparticles in bioaffinity assays : new insights and perspectives
Turun yliopiston julkaisuja. Sarja A I: Astronomica - Chemica - Physica - Mathematica : 615 (Turun yliopisto, 18.10.2019)Photon upconverting nanoparticles (UCNPs) are promising reporters for supersensitive bioaffinity assays because they can be detected completely without autofluorescence background. This is enabled by anti-Stokes shifted ...
