Selaus oppiaineen mukaan kokoelmassa VäitöskirjatFarmakologia, lääkekehitys ja lääkehoito
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Calcium signaling and neuropeptide Y in experimental models of heart failure
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica-Odontologica : 1508 (Turun yliopisto, 13.11.2020)Despite advances in medical therapy and interventional procedures, heart failure carries a dismal prognosis. Calcium has a central role in controlling the contractility of the heart, and the sarcoplasmic reticulum Ca2+ ... -
Cavity-based negative images in molecular docking
Turun yliopiston julkaisua -Annales Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1577 (Turun yliopisto, 01.10.2021)In drug development, computer-based methods are constantly evolving as a result of increasing computing power and cumulative costs of generating new pharmaceuticals. With virtual screening (VS), it is possible to screen ... -
Cellular regulation of the norepinephrine transporter
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1336 (Turun yliopisto, 23.02.2018)The norepinephrine (NE) transporter (NET) mediates high-affinity uptake of the neurotransmitter NE in central and peripheral noradrenergic neurons. NET has a critical function in controlling the synaptic levels of NE and ... -
Fadolmidine – an alpha2-adrenoceptor agonist for spinal analgesia : analgesic effect and safety in preclinical in vivo models
Turun yliopiston julkaisua -Annales Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1525 (Turun yliopisto, 29.01.2021)Pharmacological activation of α2-adrenoceptors is known to induce a characteristic pattern of pharmacodynamic responses including sedation, bradycardia, initial hypertension followed by hypotension, hypothermia and analgesia. ... -
Patient recruitment, feasibility evaluations and use of electronic health records in clinical trials - A Nordic approach
Turun yliopiston julkaisua - Annaels Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1595 (Turun yliopisto, 19.11.2021)Clinical trials constitute an important cornerstone for the development of new drugs. Patient recruitment is one of the main challenges in clinical trials. Pharmaceutical companies apply feasibility evaluations to identify ... -
The Role of maternal prenatal distress in the development and functioning of the infant cortisol stress response
Turun yliopiston julkaisua - Annaels Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1606 (Turun yliopisto, 21.01.2022)The adrenal cortex secretes cortisol during stressful situations to regulate stress reactions of several other systems, such as the immune system, to enhance coping and survival. An altered cortisol stress responsiveness ... -
The role of neuropeptide Y in the pathogenesis of the metabolic syndrome : A study of liver metabolism in transgenic mice overexpressing neuropeptide Y in noradrenergic neurons
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1392 (Turun yliopisto, 16.11.2018)The metabolic syndrome (MetS) is a set of symptoms related to obesity, predisposing patients to cardiovascular diseases, and recently hepatosteatosis has been shown to play a major role in its pathogenesis. Neuropeptide Y ... -
α2B-ADRENOCEPTORS IN THE REGULATION OF VASCULAR SMOOTH MUSCLE CELL CONTRACTION AND PROLIFERATION
Turun yliopiston julkaisuja. Sarja D, Medica - Odontologica : 1298 (Turun yliopisto, 22.09.2017)α2-Adrenoceptors (α2-ARs) belong to the large superfamily of G protein-coupled receptors (GPCRs). They mediate important actions of the endogenous catecholamines adrenaline and noradrenaline. All three α2-AR subtypes ...
