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Childhood socioeconomic status and cardiometabolic health in adulthood - The Cardiovascular Risk in Young Finns Study
Turun yliopiston julkaisua -Annales Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1481 (Turun yliopisto, 30.10.2020)The association of conventional childhood and adulthood cardiometabolic risk factors and adulthood socioeconomic status with adulthood cardiometabolic health is well-established. However, the association between childhood ... -
Diagnostic challenges in the evaluation of renal osteodystrophy – A Study using 18F-sodium fluoride positron emission tomography
Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odontologica : 1622 (Turun yliopisto, 22.04.2022)The majority of patients with end-stage kidney disease develop abnormalities in bone metabolism, referred to as renal osteodystrophy. Bone abnormalities are associated with cardiovascular morbidity and mortality. The ... -
Early life predictors of cardiovascular health in an Australian Aboriginal cohort: The Aboriginal birth cohort study
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica-Odontologica : 1619 (Turun yliopisto, 11.03.2022)BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death worldwide. In Australia, the Aboriginal population is particularly affected. This is manifested as a significantly lower life expectancy compared to ... -
Effect of bariatric surgery on liver metabolism -studies using positron emission tomography
Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1419 (Turun yliopisto, 27.04.2019)Obesity is a significant and increasing health challenge. Obesity is strongly associated with the incidence of type 2 diabetes (T2D). In obese individuals, liver insulin resistance is a major factor in the development and ... -
Endogenous regulation of brown adipose tissue in humans
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1391 (Turun yliopisto, 09.11.2018)Brown adipose tissue (BAT) is a functional and metabolically active tissue found in humans. Instead of storing energy like white adipose tissue (WAT), BAT dissipates energy in the form of heat in a process called thermogenesis. ... -
Factors associated with improved outcomes in intensively treated early rheumatoid arthritis
Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1327 (Turun yliopisto, 12.01.2018)The cornerstone of the treatment of early rheumatoid arthritis (RA) is intensive, clinical remission targeted treatment with disease-modifying antirheumatic drugs (DMARDs). The aim of the present study was to elucidate ... -
Heart failure – risk factors and the validity of diagnoses
Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odontologica : 1646 (Turun yliopisto, 19.08.2022)Heart failure (HF) is a global health problem. HF risk factors remain understudied. The roles that diabetes and sodium consumption play in HF remain unknown. Furthermore, the validity of HF diagnoses in the Finnish Hospital ... -
Home blood pressure variability − assessment and clinical significance
Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1405 (Turun yliopisto, 19.12.2018)Blood pressure (BP) variability is an independent risk factor for cardiovascular adverse events over and beyond the BP level. The clinical significance of BP variability has been extensively studied in the past few decades. ... -
Improved diagnostic accuracy for hypertension
Turun yliopiston julkaisua -Annales Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1484 (Turun yliopisto, 27.06.2020)Practical and accurate blood pressure (BP) measurement techniques are needed to ensure adequate diagnostics and treatment of hypertension. Recently, novel monitors have appeared on the market including timer-equipped home ... -
Insulin sensitivity and endocannabinoid function as risk factors for obesity: Positron emission tomography studies of insulin sensitivity and CB1 receptors
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica - Odontologica : 1767 (Turun yliopisto, 19.01.2024)Obesity is a chronic disease with epidemic proportions, and it causes serious threats for human health and wellbeing. Obesity results from long-term positive energy balance, and is characterized by excessive fat accumulation. ... -
Metabolic effects of the gastrointestinal hormone secretin with focus on brown adipose tissue
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica-Odontologica : 1560 (Turun yliopisto, 13.08.2021)In recent years, brown adipose tissue (BAT) has been of interest in metabolic research, because its activity is associated with reduced cardiovascular risk, insulin resistance and obesity. Since cardiovascular disease ... -
Metabolomics and metagenomics in hypertension
Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odontologica : 1638 (Turun yliopisto, 10.06.2022)While hypertension has been linked to various modifiable and fixed risk factors, the exact mechanisms behind blood pressure (BP) regulation and hypertension onset remain elusive. The rapid development in scientific branches ... -
Novel aspects of insulin resistance: focus on the brain. Studies using positron emission tomography
Turun yliopiston julkaisua -Annales Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1498 (11.09.2020)We are currently facing a global epidemic of obesity, which poses a great challenge for the global health. Insulin resistance is the common soil that links obesity and type 2 diabetes. Whereas most lifestyle interventions ... -
Nutritional determinants & cardiometabolic risk outcomes in children and adolescents with obesity
Turun yliopiston julkaisua -Annales Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1522 (Turun yliopisto, 20.11.2020)Total energy intake, physical activity, body size and body composition determine total energy expenditure. An imbalance between total energy intake and total energy expenditure causes obesity. Overweight and obesity remains ... -
Phenotypic and genetic subtyping of hypertension – toward personalized hypertension care
Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica-Odontologica : 1655 (Turun yliopisto, 04.11.2022)Current knowledge of phenotypic and genotypic hypertension risk factors has not been effectively translated into personalized hypertension care. The aim of this thesis was to explore hypertension subtyping by applying ... -
Physical activity, cardiorespiratory fitness and cardiovascular health : the cardiovascular risk in young Finns study
Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1330 (Turun yliopisto, 19.01.2018)Background: High physical activity and cardiorespiratory fitness may protect from the development of cardiometabolic disease outcomes but the mechanisms involved are not fully understood. Aims: The aims of this study ... -
Predictors of cardiovascular disease and mortality in patients with advanced chronic kidney disease
Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odontologica : 1629 (Turun yliopisto, 20.05.2022)Cardiovascular disease is the leading cause of high mortality in advanced chronic kidney disease (CKD) patients. Treatment and prevention of cardiovascular disease should be in focus to improve prognosis in this high-risk ... -
Regulation of intestinal metabolism in obesity and diabetes : studies using positron emission tomography
Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1355 (Turun yliopisto, 01.06.2018)The global epidemic of obesity is a challenge to healthcare systems due to the increase in the incidence of type 2 diabetes (T2D) and its associated morbidities. Although the small intestine is the first absorptive organ ... -
Regulators of central and peripheral insulin sensitivity in humans
Turun yliopiston julkaisuja. Sarja D, Medica –Odontologica : 1495 (Turun yliopisto, 21.08.2020)Insulin, secreted by pancreatic β-cells, has a preeminent role in regulating metabolism in virtually all tissues. Highly conserved through evolution, intracellular insulin signaling pathways are tightly regulated, but have ... -
Sleep-time predictors of cardiovascular complications in surgical peripheral arterial disease
Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1431 (Turun yliopisto, 14.06.2019)ABSTRACT Patients with peripheral arterial disease (PAD) undergoing surgical revascularisation are in high risk of postoperative cardiovascular complications and death, due to advancing age and multiple comorbidities ...
