Selaus oppiaineen mukaan kokoelmassa VäitöskirjatSolubiologia ja anatomia

Aineistot 1-12 / 12

    • Biological imaging of challenging targets: Peripheral nerve, mouse bones and cultured osteoclasts 

      Alanne, Maria
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica-Odontologica : 1554 (Turun yliopisto, 25.05.2021)
      During this study, advances in bioimaging have affected the biomedical research field. In this thesis, traditional microscopy and selected new techniques, namely microcomputed tomography (µCT), STED microscopy and ...

    • CD73 in triple-negative breast cancer 

      Petruk, Nataliia
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis D: Medica - Odontologica : 1761 (Turun yliopisto, 16.12.2023)
      CD73 is a membrane-bound receptor that converts AMP to adenosine. Its overexpression in tumors is associated with poor outcomes in triple-negative breast cancer (TNBC) patients. TNBC patients have limited treatment options ...

    • Crosstalk between cell adhesion and the actin cytoskeleton 

      Salomaa, Siiri
      Turun yliopiston julkaisua -Annales Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1501 (Turun yliopisto, 25.09.2020)
      In order to form tissues and to move, cells need to attach to the surrounding environment. Integrins are the major cell adhesion receptors that cells use to attach to the extracellular matrix on the outside of the cell, ...

    • Dual inhibition of the vicious cycle and tumor growth in breast and prostate cancer bone metastasis – evaluation of various therapeutic approaches in experimental mouse models 

      Suominen, Mari
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1387 (Turun yliopisto, 10.10.2018)
      Bone metastases affect the vast majority of advanced breast and prostate cancer patients with metastatic disease. Since the bone microenvironment can help cancer cells to resist treatment, it is important to find treatment ...

    • Fibroblast growth factor receptors and their inhibitors in preclinical models of breast cancer and bone metastasis 

      Kähkönen, Tiina
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1454 (Turun yliopisto, 29.11.2019)
      Advanced, metastatic stages of breast cancer are associated with high morbidity and mortality, and there is a need to establish a proof-of-concept for novel compounds that can change this scheme. Fibroblast growth factors ...

    • Functional and molecular characterization of potential oncogene Sharpin 

      Khan, Meraj Hasan
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1375 (Turun yliopisto, 31.08.2018)
      Sharpin (SHANK‐Associated RH Domain Interactor) is a multifunctional adaptor protein that interacts with other proteins and regulates their functions. For example, Sharpin is a subunit of the linear ubiquitination assembly ...

    • Mesenchymal stromal cells and circulating angiogenic cells in vascularization 

      Uusitalo-Kylmälä, Liina
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser D: Medica-Odontologica : 1659 (Turun yliopisto, 14.10.2022)
      Vascularization is essential for tissue healing and reduced ability to regrow blood vessels can contribute, for example, to impaired wound healing and bone formation after injury. Generation of functional blood vessels is ...

    • Neurofibromatosis type 1: From gene to population and cancer 

      Uusitalo, Elina
      Turun yliopiston julkaisuja D: Medica - Odontologica : 1339 (Turun yliopisto, 23.03.2018)
      Neurofibromatosis type 1 (NF1) is an autosomal dominant syndrome caused by mutations in the large and complex NF1 tumor suppressor gene on chromosome 17. NF1 is the most frequent hereditary tumor predisposition syndrome. ...

    • New insights into receptor trafficking in human cancer 

      Sahgal, Pranshu
      Turun yliopiston julkaisuja. Sarja D: Medica, Odontologica : 1398 (Turun yliopisto, 16.11.2018)
      Plasma membrane receptors play an essential role in cancer by regulating cancer-related processes such as cell proliferation and migration in response to cues from the extracellular ligands. Integrins are cell-matrix ...

    • Novel insights into filopodia function – A focus on integrin and F-actin regulation 

      Miihkinen, Mitro
      Turun yliopiston julkaisua -Annales Universitatis Turkuensis, Ser. D: Medica-Odongologica : 1585 (Turun yliopisto, 08.10.2021)
      Filopodia are actin-rich cell protrusions that are extended from the plasma membrane by different cell types in order to sense the surrounding environment. In cancer cells, the emergence of filopodia supports metastasis, ...

    • Phage-based biosensors for detection of microbes and biomarkers 

      Kulpakko, Janne
      Turun yliopiston julkaisua - Annales Universitatis Turkuensis, Ser. D: Medica-Odontologica : 1640 (Turun yliopisto, 22.06.2022)
      The detection of microbial species and communities has always been an area of great importance. Rapid methods for microbial detection are especially important in the medicine, pharmacological, and food industry. The lack ...

    • Regulation of Schwann cells and osteoclasts with an emphasis on NF1-deficient cells 

      Pennanen, Paula
      Turun yliopiston julkaisuja. Sarja D, Medica – Odontologica : 1434 (Turun yliopisto, 08.06.2019)
      ABSTRACT Neurofibromatosis type 1 (NF1) is a dominantly inherited cancer predisposition syndrome, which affects one in 2000 individuals worldwide. NF1 exhibits a variety of clinical symptoms. Neurofibromas, the hallmarks ...