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Temporal trends and outcomes in aortic and mitral valve surgery in Finland
(Turun yliopisto, 2022-01-21)
Aortic valve surgery is the most common type of heart valve surgery in western countries. The main causes for aortic valve surgery are aortic valve stenosis and regurgitation. Mitral valve regurgitation is the most common ...
Anaesthesia for electroconvulsive therapy in Finland – Variation in clinical practices and the management of adverse effects
(Turun yliopisto, 2026-01-16)
Electroconvulsive therapy (ECT) is a well-established treatment for severe depression and remains the most effective option when rapid symptom relief is required, such as in acutely suicidal patients. This thesis aims to ...
Metabolic profiling in anaesthesiology and intensive care: Pharmacometabolic effects of anaesthetic agents and metabolomics after out-of-hospital cardiac arrest
(Turun yliopisto, 2025-06-06)
In metabolomics a “snapshot” of the current metabolic state of an organism, a metabolic profile, is obtained from biofluid samples. Despite emerging metabolomics studies in the field of clinical anaesthesia and intensive ...
Data collection in helicopter emergency medical services
(Turun yliopisto, 2021-05-28)
Prehospital critical care, especially helicopter emergency medical services (HEMS), is a costly but vital part in the chain of survival for a critically deteriorated patient. The quality assessment and outcome measures of ...
Intranasal dexmedetomidine in perioperative orthopedic anesthesia: Pharmacodynamic and harmacokinetic studies in adult patients
(Turun yliopisto, 2025-04-04)
Effective pain management is critical to ensure optimal recovery after orthopedic procedures, but postoperative pain remains an issue despite the use of multimodal analgesia. Alpha-2-agonist dexmedetomidine could be a ...
Probing the (Un)Conscious Brain : EEG and PET Studies on Healthy Human Subjects Using Propofol, Dexmedetomidine and Natural Sleep
(Turun yliopisto, 2022-09-09)
Consciousness cannot be objectively measured. By employing anesthesia and
neurophysiologic measurements to study human consciousness, unconsciousness
has been found to associate with suppression of regional brain activity ...
Paediatric spinal surgery and perioperative management
(Turun yliopisto, 2023-05-26)
The aim of this dissertation is to improve perioperative management of adolescent patients undergoing posterior spinal fusion surgery. Posterior spinal fusion surgery is one of the most common major surgical procedures in ...
Pharmacokinetics and effects of extravascularly administered dexmedetomidine : studies on pediatric and adult patients, and healthy adult volunteers
(Turun yliopisto, 2019-11-01)
Patients undergoing surgery and other invasive procedures need sedation and pain relief. Many unpleasant sensations and experiences can be reduced by administration of conventional sedative and analgesic drugs, but most ...
Effect of antimycotics and rifampicin on the pharmacokinetics of buprenorphine and the feasibility of sublingual fentanyl for procedural sedation
(Turun yliopisto, 2020-09-04)
Buprenorphine and fentanyl are opioids, which have been clinically used for decades. Buprenorphine is traditionally prescribed for maintenance therapy in opioid dependent patients and to a lesser extent in the treatment ...
The effects of dexmedetomidine on cerebral glucose metabolism, systemic cytokine release and cerebral autoregulation: Studies on healthy volunteers and aneurysmal subarachnoid haemorrhage patients
(Turun yliopisto, 2022-12-02)
Dexmedetomidine is a very selective α2-agonist that has become a popular sedative in the intensive care unit. It has characteristics that make it appealing especially for neurologically compromised patients. Aneurysmal ...