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Bacterial pathogens cause severe infections in humans. The emergence of multiresistant bacteria requires the development of new antimicrobial strategies. Bacteria utilize various virulence mechanisms to promote their ...

For decades, actinomycetes have been a major source of antibacterial and antiproliferative compounds, providing medicine with drugs invaluable for the treatment of a variety of diseases and types of cancer. The discovery ...

Anthracyclines, microbial natural products primarily produced by soil-dwelling Streptomyces bacteria, are potent chemotherapeutic agents used clinically worldwide. However, despite their potent antiproliferative activities, ...

Within the group of filamentous fungi, Aspergillus flavus is a prominent species because of its capability to produce aflatoxin B1 (AFB1). The consumption of AFB1-contaminated food and feed causes aflatoxicosis, which can ...

Embigin (Gp70) is a transmembrane glycoprotein belonging to the basigin subgroup of the immunoglobulin superfamily. Embigin functions as an ancillary protein for monocarboxylate transporters (MCT) and may regulate ...

Antimicrobial resistance is an imminent threat that is expected to kill 10 million people per year by 2050. Natural products have been a major source of antimicrobial compounds and encompass a chemical space far greater ...

Glutathione transferases (GSTs) represent a ubiquitous large family of multifunctional enzymes which protect cellular macromolecules from reactive electrophiles. GSTs catalyse the nucleophilic addition of glutathione to ...

The expression and replication of genetic information forms the basis of life. The first step of gene expression, the transcription of DNA into RNA, is carried out in all organisms by multisubunit RNA polymerase enzymes ...

In photosynthesis, light energy is converted to chemical energy, which is consumed for carbon assimilation in the Calvin-Benson-Bassham (CBB) cycle. Intensive research has significantly advanced the understanding of how ...

Integrins regulate cell adhesion, migration and architecture which play a role both in development of healthy tissues and disease. While integrins have been widely studied amongst models, the way their availability acts ...