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Characterization of cytokine binding and its implications in the physiology of Aggregatibacter actinomycetemcomitans
(Turun yliopisto, 2019-06-07)
Bacterial pathogens cause severe infections in humans. The emergence of multiresistant bacteria requires the development of new antimicrobial strategies. Bacteria utilize various virulence mechanisms to promote their ...
Translocation mechanism of the multisubunit RNA polymerase
(Turun yliopisto, 2018-06-08)
The expression and replication of genetic information forms the basis of life. The first step of gene expression, the transcription of DNA into RNA, is carried out in all organisms by multisubunit RNA polymerase enzymes ...
Structural studies of glutathione transferases towards the development of novel applications and drug design
(Turun yliopisto, 2022-10-21)
Glutathione transferases (GSTs) represent a ubiquitous large family of multifunctional enzymes which protect cellular macromolecules from reactive electrophiles. GSTs catalyse the nucleophilic addition of glutathione to ...
Molecular Mechanisms and Interactions in Regulation of Photosynthetic Reactions
(Turun yliopistoAnnales Universitatis Turkuensis A I 493, 2014-10-24)
In photosynthesis, light energy is converted to chemical energy, which is consumed for carbon assimilation in the Calvin-Benson-Bassham (CBB) cycle. Intensive research has significantly advanced the understanding of how ...
Biosynthesis and evolution of anthracyclines
(Turun yliopisto, 2021-08-20)
Natural products are a rich source of medication leads, accounting for about twothirds of all antibiotics and one-third of all anticancer drugs currently in use. Anthracyclines, which belong to the type II family of aromatic ...
Metabolic pathway engineering of actinomycetes for novel antibiotics discovery
(Turun yliopisto, 2022-01-21)
Microbes harbouring a profound wealth of chemical space have instigated tremendous attention for developing crucial therapeutic drugs. The genes encoding the enzymes responsible for synthesizing these specialized metabolites ...
Genome Mining Actinobacteria: Eliciting the Production of Natural Products
(Turun yliopisto, 2023-06-16)
Antimicrobial resistance is an imminent threat that is expected to kill 10 million people per year by 2050. Natural products have been a major source of antimicrobial compounds and encompass a chemical space far greater ...
The role of the DNA uptake machinery in the virulence of Aggregatibacter actinomycetemcomitans
(Turun yliopisto, 2023-12-01)
Biofilm infections pose a significant health threat owing to their increased resistance to antibiotics. The oral inflammatory disease periodontitis is caused by a multispecies biofilm. One species associated with periodontitis ...