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Recognition of double-helical DNA and RNA by modified triplex-forming oligonucleotides and peptide nucleic acids
(Turun yliopisto, 2019-10-11)
Triplex-forming oligonucleotides (TFOs) have received considerable interest because of their ability to recognize double-helical DNA and RNA sequenceselectively. Sequence-selective binding to double-helical DNA would enable ...
[18F]F2 – New production methods and applications
(Turun yliopisto, 2018-12-19)
Fluorine-18 is a positron emitting radioisotope. It has a half-life of 109.8 min, a simple decay profile and low positron energy as a result of which properties fluorine-18 is an excellent candidate for use in the production ...
Energy transfer in luminescent lanthanoid chelates
(Turun yliopisto, 2020-05-29)
Luminescent lanthanoid complexes are widely utilized, especially in the medical diagnostics. The complexes have been much studied and ligands with high quantum efficiency have been developed for different lanthanoid ions ...
Application of NMR metabolomics profiling on questions arising from molecular biology
(Turun yliopisto, 2018-04-20)
In recent years, there has been an increasing interest in utilizing nuclear magnetic resonance (NMR) spectroscopy metabolomics to understand different biochemical mechanisms of living organisms. Metabolomic profiling can ...
Synthetic hackmanites and their optical properties – from theory to applications
(Turun yliopisto, 2019-05-17)
Synthetic hackmanite is a material that resembles the natural mineral, hackmanite. The structure of hackmanite, Na8Al6Si6O24(Cl,S)2, together with its simple preparation with solid state synthesis enables the doping of ...
Aminophenolato complexes of Mo, W and V In catalytic alkene epoxidation and catechol oxidation
(Turun yliopisto, 2021-11-05)
Mo, W and V are found naturally in metalloenzymes such as the Mo/W oxotransferases and the V haloperoxidases (VHPOs). These enzymes catalyze oxidation reactions related to C, N, S metabolism as well as halogenation. Cu and ...
Structure elucidation and ruminant-related bioactivities of purified proanthocyanidins
(Turun yliopisto, 2020-12-15)
In this thesis work, a group of natural oligomers and polymers called proanthocyanidins was studied via multiple chemical approaches. At first, the proanthocyanidins were purified from eleven Finnish plant species with a ...
Radiosynthesis of [¹⁸F]F-DPA with various molar activities for the imaging of neuroinflammation
(Turun yliopisto, 2019-06-14)
The use of radioisotopes as a means to non-invasively look into living subjects influenced both diagnostic and therapeutic medicine in the past century. Nowadays positron emission tomography (PET), employing short-lived ...
Photoluminescence quenchers in drug discovery
(Turun yliopisto, 2021-12-03)
During the drug discovery process molecular libraries containing millions of molecules are screened to find a single potential drug with the highest potency and efficacy over unwanted side-effects. The whole drug development ...
Novel 19F NMR sensors for the characterization of higher-order secondary structures of DNA and RNA
(Turun yliopisto, 2018-06-14)
Both DNA and RNA can fold into a variety of non-canonical structures. Non-canonical structures, such as triplexes and G-quadruplexes, are an active research area due to their biological significance and therapeutic potential. ...