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While hypertension has been linked to various modifiable and fixed risk factors, the exact mechanisms behind blood pressure (BP) regulation and hypertension onset remain elusive. The rapid development in scientific branches ...

Cardiovascular disease is the leading cause of high mortality in advanced chronic kidney disease (CKD) patients. Treatment and prevention of cardiovascular disease should be in focus to improve prognosis in this high-risk ...

Brown adipose tissue (BAT) is a functional and metabolically active tissue found in humans. Instead of storing energy like white adipose tissue (WAT), BAT dissipates energy in the form of heat in a process called thermogenesis. ...

The association of conventional childhood and adulthood cardiometabolic risk factors and adulthood socioeconomic status with adulthood cardiometabolic health is well-established. However, the association between childhood ...

Bone marrow (BM) is the porous tissue found inside bones that consists of adipose tissue, hematopoietic cells, and other stem cells. BM adipose tissue has been shown to have high basal glucose uptake in humans, exceeding ...

Finnish health care registers are frequently used for research, but little attention has been paid on the validity of diagnoses in these registers, especially in the field of rheumatology. This dissertation investigated ...

The majority of patients with end-stage kidney disease develop abnormalities in bone metabolism, referred to as renal osteodystrophy. Bone abnormalities are associated with cardiovascular morbidity and mortality. The ...

Insulin, secreted by pancreatic β-cells, has a preeminent role in regulating metabolism in virtually all tissues. Highly conserved through evolution, intracellular insulin signaling pathways are tightly regulated, but have ...

In recent years, brown adipose tissue (BAT) has been of interest in metabolic research, because its activity is associated with reduced cardiovascular risk, insulin resistance and obesity. Since cardiovascular disease ...

Thyroid dysfunctions, especially subclinical forms, are common and could be related to an elevated cardiovascular risk. Previous data on the associations of thyroid function with cardiovascular disease entities and their ...