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The study focuses on proteins Securin, Pttg1IP and Separase, involved in metaphase-anaphase transition of mitosis, and microRNAs -494, -205, -21 and -126 in association with cell proliferation. The aim is to demonstrate ...

Breast cancer is the most common malignancy among women. It remains a major cause of mortality among women, although the five-year survival of breast cancer patients is about 90%. To aid in the clinical treatment decisions, ...

The risk of recurrence of stage II colorectal cancer is difficult to predict. A part of recurrences take place among patients without any of the known high-risk factors such as lymphovascular invasion or preoperative ...

Inhibition of tumor suppressor Protein Phosphatase 2A (PP2A) has been denoted as one of the minimal requirements for malignant transformation of a human cell. In cancer, PP2A activity is in the majority of cases inhibited ...

Genetic instabilities drive melanoma development, disrupting immune editing and leading to resistance against revolutionary therapies like immune checkpoint therapies (ICT), as seen in uveal (UM) and cutaneous (CM) subtypes. ...

ABSTRACT Tubo-ovarian high-grade serous carcinoma (HGSC) is the most common and lethal subtype of ovarian cancer, typically diagnosed at an advanced stage due to absence of specific symptoms and specific clinical biomarkers. ...

Recent advances in various treatment modalities, including targeted therapies, combination therapies, and immunotherapies, have improved the prognosis for many types of cancer. However, cancer treatments often provide a ...

Cancer is characterized by aberrant activation of phosphorylation signalling cascades. However, despite the critical role of phosphatases in protein phosphorylation, their contribution to cancer cell signalling is only ...

B lymphocytes are an important part of the adaptive immune system. As one of their main functions, B cells can recognise specific antigens via their B cell receptor and produce antibodies that help clear infections. In ...

Basal-like breast cancer (BLBC) is an aggressive and therapeutically most challenging breast cancer subtype, due to a lack of druggable breast specific surface receptors (ER, PR, HER2) or driver mechanisms. BLBC patients ...