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Prodrug strategies of antiviral nucleotides: Studies on enzymatically and thermally removable phosphate protecting groups
(Turun yliopistoTurun yliopiston julkaisuja - Annales Universitatis Turkuensis. Sarja - ser. AI osa - tom. 522, 2015-09-18)
Antiviral nucleosides are compounds that are used against viruses, such as human immunodeficiency virus (HIV) and hepatitis C virus (HCV). To act as therapeutic agent, the antiviral nucleoside needs to be phosphorylated ...
Reactions of Chlorambucil and its main metabolite, Phenylacetic Acid Mustard, with 2’-deoxyribonucleosides and Calf Thymus DNA
(Turun yliopistoAnnales Universitatis Turkuensis AI 401, 2009-10-23)
Chlorambucil is an anticancer agent used in the treatment of a variety of cancers, especially in chronic lymphocytic leukemia, and autoimmune diseases. Nevertheless, chlorambucil is potentially mutagenic, teratogenic and ...
Halogen hectorites : smectites designed to luminesce
(Turun yliopisto, 2017-12-15)
The smectites represent a versatile class of clay minerals, offering possibilities of applications in several industrial and scientific fields. The hectorite belongs to this class, but it has the advantage of production ...
Phenolics of the Inner Bark of Silver Birch: Characterization and Intraspecific Variation
(Turun yliopistoAnnales Universitatis Turkuensis A I 477, 2013-12-13)
This thesis describes work related to the in-depth characterization of the phenolic compounds of silver birch (Betula pendula) inner bark. Phenolic compounds are the most ubiquitous class of plant secondary compounds. The ...
Tautomerism and Fragmentation of Biologically Active Hetero Atom (O, N)-Containing Acyclic and Cyclic Compounds Under Electron Ionization
(Turun yliopistoAnnales Universitatis Turkuensis A I 392, 2009-04-17)
In this thesis a total of 86 compounds containing the hetero atoms oxygen and nitrogen were studied under electron ionization mass spectrometry (EIMS). These compounds are biologically active and were synthesized by various ...
Brown algal phlorotannins: Improving and applying chemical methods
(Turun yliopistoAnnales Universitatis Turkuensis AI 381, 2008-02-22)
Phlorotannins are the least studied group of tannins and are found only in brown algae. Hitherto the roles of phlorotannins, e.g. in plant-herbivore interactions, have been studied by quantifying the total contents of the ...
Artificial Ribonucleases: Oligonucleotides Conjugated with Metal Ion Chelates of Azacrowns
(Turun yliopistoAnnales Universitatis Turkuensis A I 494, 2014-11-07)
Ribonucleic acid (RNA) has many biological roles in cells: it takes part in coding, decoding, regulating and expressing of the genes as well as has the capacity to work as a catalyst in numerous biological reactions. These ...
Flavonoids and other phenolic compounds: characterization and interactions with lepidopteran and sawfly larvae
(Turun yliopistoAnnales Universitatis Turkuensis A I 496, 2014-11-14)
This thesis focuses on flavonoids, a subgroup of phenolic compounds produced by plants, and how they affect the herbivorous larvae of lepidopterans and sawflies. The first part of the literature review examines different ...
Graphene from Graphite by Chemical and Physical Techniques.
(Turun yliopistoAnnales Universitatis Turkuensis A I 500, 2014-12-09)
Graphene is a material with extraordinary properties. Its mechanical and electrical properties are unparalleled but the difficulties in its production are hindering its breakthrough in on applications. Graphene is a ...
Frequency-Domain and Wide-Pulse Time-Domain Measurements of Lanthanide Luminescence and Lanthanide-Based Resonance Energy Transfer
(Turun yliopistoAnnales Universitatis Turkuensis A I 436, 2012-02-10)
Resonance energy transfer (RET) is a non-radiative transfer of the excitation energy from the initially excited luminescent donor to an acceptor. The requirements for the resonance energy transfer are: i) the spectral ...