Hae

Mo, W and V are found naturally in metalloenzymes such as the Mo/W oxotransferases and the V haloperoxidases (VHPOs). These enzymes catalyze oxidation reactions related to C, N, S metabolism as well as halogenation. Cu and ...

During the drug discovery process molecular libraries containing millions of molecules are screened to find a single potential drug with the highest potency and efficacy over unwanted side-effects. The whole drug development ...

Research on therapeutically effective oligonucleotides (antisense oligonucleotides, ASOs and small interfering RNAs, siRNAs) has grown rapidly during the last decades. Oligonucleotide (ON) therapeutics are nowadays an ...

The chemical diversity of plants is enormous as plants produce a variety of compounds that play key roles, for instance, in the growth, defence and reproduction of plants. This diversity is not well recognised in chemistry ...

Bringing a new drug to the market is an expensive and long process. Typically, more than ten years and a billion dollars needs to be spent so the whole process is a big investment for a pharma company. The hit generation ...

Redox-active metal organic complexes with ‘non-innocent’ ligands are promising candidates when it comes to developing novel homogenous catalysts. The related complexes have gained interest since they could be utilized as ...

Proteins are the building blocks of life, and mainly perform their roles through protein-protein interactions (PPIs). Thus, PPIs are essential to the normal function of the cells and the body, and disturbances in these ...

Research on metal-mediated base pairing has proceeded rapidly during the last decades, and metal-mediated base pairs have become one noteworthy option for developing new DNA-based biological or nanotechnological applications. ...

Based on Watson—Crick base pairing principle, therapeutic oligonucleotides bear the potential to either inhibit or alter protein synthesis. Replacing or augmenting Watson—Crick base paring by metal coordination offers a ...

Metal-mediated base pairs have attracted considerable attention during the past decades for their potential in bio- and nanotechnological applications. The introduction of metal ions into DNA or RNA not only stabilizes ...