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Within the group of filamentous fungi, Aspergillus flavus is a prominent species because of its capability to produce aflatoxin B1 (AFB1). The consumption of AFB1-contaminated food and feed causes aflatoxicosis, which can ...

Glutathione transferases (GSTs) represent a ubiquitous large family of multifunctional enzymes which protect cellular macromolecules from reactive electrophiles. GSTs catalyse the nucleophilic addition of glutathione to ...

Integrins regulate cell adhesion, migration and architecture which play a role both in development of healthy tissues and disease. While integrins have been widely studied amongst models, the way their availability acts ...

Natural products are a rich source of medication leads, accounting for about twothirds of all antibiotics and one-third of all anticancer drugs currently in use. Anthracyclines, which belong to the type II family of aromatic ...

Energy consumption, especially electricity demand, is continually rising, while non-renewable fossil energy sources such as petroleum, natural gas, and coal are depleting. Fossil energy production also causes greenhouse ...

Microbes harbouring a profound wealth of chemical space have instigated tremendous attention for developing crucial therapeutic drugs. The genes encoding the enzymes responsible for synthesizing these specialized metabolites ...

Biofilm infections pose a significant health threat owing to their increased resistance to antibiotics. The oral inflammatory disease periodontitis is caused by a multispecies biofilm. One species associated with periodontitis ...

Thermophilic enzymes are characterized by their ability to resist temperature while maintaining their catalytic efficiency. They are mostly found in organisms, such as bacteria or fungi, that reside in natural habitats ...

RNA polymerases (RNAPs) synthesize RNA using DNA or RNA as a template. Accurate RNA synthesis is essential for cellular functions and viral RNA replication, so RNAPs actively select the right nucleotides by probing for ...