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Structural studies of glutathione transferases towards the development of novel applications and drug design
(Turun yliopisto, 2022-10-21)
Glutathione transferases (GSTs) represent a ubiquitous large family of multifunctional enzymes which protect cellular macromolecules from reactive electrophiles. GSTs catalyse the nucleophilic addition of glutathione to ...
Biosynthesis and evolution of anthracyclines
(Turun yliopisto, 2021-08-20)
Natural products are a rich source of medication leads, accounting for about twothirds of all antibiotics and one-third of all anticancer drugs currently in use. Anthracyclines, which belong to the type II family of aromatic ...
Metabolic pathway engineering of actinomycetes for novel antibiotics discovery
(Turun yliopisto, 2022-01-21)
Microbes harbouring a profound wealth of chemical space have instigated tremendous attention for developing crucial therapeutic drugs. The genes encoding the enzymes responsible for synthesizing these specialized metabolites ...
The role of the DNA uptake machinery in the virulence of Aggregatibacter actinomycetemcomitans
(Turun yliopisto, 2023-12-01)
Biofilm infections pose a significant health threat owing to their increased resistance to antibiotics. The oral inflammatory disease periodontitis is caused by a multispecies biofilm. One species associated with periodontitis ...