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Aineistot 151-160 / 226
Integrin activity regulation in mechanosensing: Integrin beta1 activity and extracellular matrix crosstalk
(Turun yliopisto, 2021-09-10)
Cell functions are highly dependent on the physical properties of the extracellular matrix (ECM). Integrins are transmembrane receptors providing the main molecular link that attaches cells to the ECM. The distinct biochemical ...
Cellular vulnerabilities of glioblastoma
(Turun yliopisto, 2021-10-15)
Glioblastoma (GB) is the most fatal and frequent malignant brain tumor, and it is driven by multiple oncogenic pathways. Despite intensive screening of genomic, transcriptomic, metabolic, and post-translational landscape ...
Novel insights into filopodia function – A focus on integrin and F-actin regulation
(Turun yliopisto, 2021-10-08)
Filopodia are actin-rich cell protrusions that are extended from the plasma membrane by different cell types in order to sense the surrounding environment. In cancer cells, the emergence of filopodia supports metastasis, ...
Immunoregulatory roles of CD73 in lymphatic endothelial and myeloid cells
(Turun yliopisto, 2021-01-29)
The immune system is a fascinating product of the interaction and cooperation of amultitude of cells and tissues. It is thereby able to distinguish between “friend” and “foe” and protect the host from a great variety of ...
Implementation of modern methods to identify DNA methylation marks for episodic memory impairment and Alzheimer’s disease
(Turun yliopisto, 2020-10-23)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and a common cause of dementia worldwide. The pathogenic mechanisms of AD are not completely understood. Both genetic and external factors, like lifestyle ...
Uncovering the role of DICER and pericentric heterochromatin expression during spermatogenesis
(Turun yliopisto, 2020-10-30)
Male germ cell differentiation is a complex process that includes mitotic proliferation, meiosis and haploid differentiation phase, during which the cell undergoes dramatic morphological changes to produce mature spermatozoa. ...
HLA-A*24 and B*39 alleles in type 1 diabetes risk
(Turun yliopisto, 2020-12-11)
Type 1 diabetes is an autoimmune disease, and it is one of the most common chronic diseases of childhood. An asymptomatic pre-diabetes period preceding the clinical onset is characterized by autoantibodies against pancreatic ...
Crosstalk between cell adhesion and the actin cytoskeleton
(Turun yliopisto, 2020-09-25)
In order to form tissues and to move, cells need to attach to the surrounding environment. Integrins are the major cell adhesion receptors that cells use to attach to the extracellular matrix on the outside of the cell, ...
Old acquaintances and new perspectives into testicular development and function
(Turun yliopisto, 2020-11-27)
Testicular development and function are complex processes that involve synchronization of the proliferation, apoptosis, and differentiation of specific somatic and germ cells to ensure lifelong fertility. Dysregulation of ...
Molecular imaging and immunotherapy in atherosclerotic cardiovascular disease
(Turun yliopisto, 2020-11-28)
Atherosclerotic cardiovascular disease (ASCVD) is a disorder that affects both heart and blood vessels. It is caused by atherosclerosis, a chronic, low-grade inflammatory disease, which is characterized by the accumulation ...