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Lymphatic endothelial cells regulate traffic in lymph nodes
(Turun yliopisto, 2020-10-23)
Afferent lymphatic vessels transport leukocytes and soluble molecules from the periphery to lymph nodes. These vessels are lined with lymphatic endothelial cells (LEC), which are also present in lymph node sinuses. Lymph ...
Screening of novel therapeutic targets and risk alleles for cardiac disorders
(Turun yliopisto, 2020-11-27)
Ischemic heart disease is the leading cause of death globally, even though the prognosis of the disease has improved with advancing treatments. One particular phenomenon which could be treated more effectively is ...
Pathogenesis of LMNA-related dilated cardiomyopathy
(Turun yliopisto, 2022-03-04)
Dilated cardiomyopathy (DCM) is a progressive myocardial disease that leads to dilatation of cardiac ventricles, reduced contractile force, and a high risk of sudden cardiac death. The second most common gene mutated in ...
Regulation of cell growth, death, and polarization by ERBB4
(Annales Universitatis Turkuensis D 991Turun yliopisto, 2011-11-25)
<b>Regulation of cell growth, death, and polarization by <i>ERBB4</i></b>
ErbB4 is a member of the epidermal growth factor receptor (EGFR, ErbB) family. The other members are EGFR, ErbB2 and ErbB3. ErbB receptors are ...
Biosynthesis of Yersinia enterocolitica serotype O:3 lipopolysaccharide outer core
(Annales Universitatis Turkuensis D 927Turun yliopisto, 2010-11-19)
Lipopolysacharide (LPS) present on the outer leaflet of Gram-negative bacteria is important for the adaptation of the bacteria to the environment. Structurally, LPS can be divided into three parts: lipid A, core and ...
Application of RNAi to silence tartrate-resistant acid phosphatase: unexpected effects on the monocyte-macrophage lineage
(Turun yliopisto, 2007-11-02)
<b>Tartraatti-resistentin happaman fosfataasin hiljentäminen RNAi menetelmällä: odottamaton vaikutus monosyytti-makrofagi linjan soluissa</b>
RNA interferenssi (RNAi) eli RNA:n hiljentyminen löydettiin ensimmäisenä ...
Dissecting the molecular mechanisms of breast cancer bone metastasis for therapeutic targeting
(Annales Universitatis Turkuensis D 1008Turun yliopisto, 2012-04-14)
Breast cancer that has metastasized to bone is currently an incurable disease, causing
significant morbidity and mortality. The aim of this thesis work was to elucidate
molecular mechanisms of bone metastasis and thereby ...
Use of preclinical and early clinical data for dose selection of a selective estrogen receptor modulator toremifene in treatment of breast cancer
(Annales Universitatis Turkuensis D 1015Turun yliopisto, 2012-06-15)
In development of human medicines, it is important to predict early and accurately enough
the disease and patient population to be treated as well as the effective and safe dose range
of the studied medicine. This is ...
Regulation of ErbB4 signaling by post-translational modifications
(Annales Universitatis Turkuensis D 1265Turun yliopisto, 2017-02-10)
ErbB4 is a member of the epidermal growth receptor family (EGFR/ErbB1, ErbB2, ErbB3, ErbB4) of receptor tyrosine kinases. ErbB receptors are activated by extracellular growth factor ligands, and control the ...
Biological imaging of challenging targets: Peripheral nerve, mouse bones and cultured osteoclasts
(Turun yliopisto, 2021-05-25)
During this study, advances in bioimaging have affected the biomedical research field. In this thesis, traditional microscopy and selected new techniques, namely microcomputed tomography (µCT), STED microscopy and ...