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Diffusion Tensor Imaging as a Diagnostic and Research Tool: A Study on Preterm Infants
(Annales Universitatis Turkuensis D 1096Turun yliopisto, 2014-01-17)
Diffusion tensor imaging (DTI) is an advanced magnetic resonance imaging (MRI) technique. DTI is based on free thermal motion (diffusion) of water molecules. The properties of diffusion can be represented using parameters ...
Luminescence-based assay methods in drug discovery
(Annales Universitatis Turkuensis D 982Turun yliopisto, 2011-10-28)
The drug discovery process is facing new challenges in the evaluation process of the lead compounds as the number of new compounds synthesized is increasing. The potentiality of test compounds is most frequently assayed ...
Receptors and endocytosis of coxsackievirus A9
(Annales Universitatis Turkuensis D 1067Turun yliopisto, 2013-05-25)
Coxsackievirus A9 (CV-A9) belongs to human enteroviruses within family Picornaviridae, which are the main cause of aseptic meningitis. In addition, CV-A9 causes a wide range of other clinical manifestations of acute disease ...
Herpes simplex virus type 1 (HSV-1) pathogenesis and HSV gene therapy of experimental autoimmune encephalomyelitis
(Annales Universitatis Turkuensis D 1074Turun yliopisto, 2013-06-14)
The aim of this thesis was to develop new herpes simplex virus (HSV) vectors for gene therapy of experimental autoimmune encephalomyelitis (EAE), the principal model of multiple sclerosis (MS), and to study the pathogenesis ...
Cell surface interactions of coxsackievirus A9 and human parechovirus 1
(Annales Universitatis Turkuensis D 1283Turun yliopisto, 2017-05-12)
Coxsackievirus A9 (CV-A9) and human parechovirus 1 (HPeV-1) belong to family Picornaviridae, genera Enterovirus and Parechovirus respectively. CV-A9 has been associated with aseptic meningitis, myocarditis in addition to ...
A Farewell to Flat Biology. Three-dimensional Cell Culture Models in Cancer Drug Target Identification and Validation
(Annales Universitatis Turkuensis D 1028Turun yliopisto, 2012-09-14)
Cells of epithelial origin, e.g. from breast and prostate cancers, effectively differentiate into complex multicellular structures when cultured in three-dimensions (3D) instead of conventional two-dimensional (2D) adherent ...
Characterization of Gamma-Secretase-Mediated Cleavage of Receptor Tyrosine Kinases
(Turun yliopisto, 2021-09-10)
ABSTRACT
Receptor tyrosine kinases (RTK) are a family of cell surface receptors consisting of 55 members. RTKs regulate intracellular signaling pathways that control fundamental cellular processes including differentiation, ...
From Unspecific Quenching to Specific Signaling: Functional GTPase Assays Utilizing Quenching Resonance Energy Transfer (QRET) Technology
(Turun yliopisto, 2015-04-17)
The aim of the work presented in this study was to demonstrate the wide applicability of a single-label quenching resonance energy transfer (QRET) assay based on time-resolved lanthanide luminescence. QRET technology is ...
Analyzing change in medication use - statistical approaches
(Annales Universitatis Turkuensis D 1241Turun yliopisto, 2016-08-12)
The objective of this study was to gain an understanding of the effects of population heterogeneity, missing data, and causal relationships on parameter estimates from statistical models when analyzing change ...
Securin, Cdc20 and Cdc27 in predicting the outcome of human breast cancer
(Annales Universitatis Turkuensis D 1180Turun yliopisto, 2015-08-28)
Deregulated proliferation has been recognized among the most important factors promoting breast cancer development and progression. The aim of the project is to gain understanding of the role of specific ...