Hae
Aineistot 21-25 / 25
Hydrophobicity and lipid interactions of hydrolysable tannins
(Turun yliopisto, 2023-09-29)
This thesis work focused on a specialized plant metabolite group called hydrolysable tannins with the aim of expanding the knowledge on their hydrophobicity, interactions with lipid membranes and antibacterial capacity. ...
Organomercury oligonucleotides as artificial ribonucleases
(Turun yliopisto, 2024-05-10)
Antisense oligonucleotides (ASOs) leverage the natural catalytic activity of RNases H to target specific RNA sequences for degradation. However, the challenge lies in incorporating chemical modifications into ASOs to enhance ...
N-Methoxyoxazolidineligation in oligonucleotides
(Turun yliopisto, 2024-09-27)
Vedessä tapahtuvia kytkentäreaktioita hyödynnetään modernissa lääkekehityksen kemiassa ja bioteknologisissa sovelluksissa. Esimerkiksi DNA-templatoidun synteesin avulla valmistetaan laajoja molekyylikirjastoja, jotka ...
Radiolabeling of spherical oligonucleotides for targeted and pretargeted PET imaging : Biological evaluation of structural effects by using a tetrazine [¹⁸F]fluoroglycoconjugate
(Turun yliopisto, 2024-09-13)
Positron emission tomography (PET) is a sensitive and non-invasive molecular imaging modality with various applications, including drug discovery and the development of novel therapeutics evaluation at an early stage. ...
Monitoring cellular Guanosine triphosphate (GTP) and GTP associated proteins
(Turun yliopisto, 2024-03-01)
Guanosine-5'-triphosphate (GTP) is an essential molecule for cell survival and function. Although free GTP plays a crucial role in several cellular processes, most studies focus solely on the protein bound GTP and its ...