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ABSTRACT Endothelium is the barrier between the blood and tissue stroma. Cells and macromolecules are selectively allowed to traffic through the endothelium to maintain homeostasis. Besides the paracellular transport ...

Acute appendicitis presents as two different diseases: uncomplicated and complicated acute appendicitis. The majority are uncomplicated, which may be treated with antibiotics instead of surgery and possibly even with ...

T-helper cells are an important part of the immune system and adaptive immunity. Over the course of the immune response, under the influence of various cytokines, T-helper cells differentiate into various subsets each of ...

Type 1 diabetes (T1D) is a complicated autoimmune disease with largely unknown disease mechanisms. The diagnosis is preceded by a long asymptomatic period of autoimmune activity in the insulin-producing pancreatic islets. ...

T helper cells are critical components of adaptive immune system contributing to self/ nonself-recognition, pathogen elimination and pathogenesis of immune-associated diseases. Understanding the underlying mechanisms ...

The HLA region accounts for approximately half of the genetic susceptibility in type 1 diabetes. The strongest genetic association with type 1 diabetes (T1D) is conferred by HLA class II alleles, where particular combinations ...

Type 1 diabetes is an autoimmune disease, and it is one of the most common chronic diseases of childhood. An asymptomatic pre-diabetes period preceding the clinical onset is characterized by autoantibodies against pancreatic ...

The detection of early markers is the key issue in predicting the outcome of inflammatory diseases such as type 1 diabetes and atherosclerosis. Whilst biochemical testing approaches have improved prediction of inflammatory ...

ABSTRACT Sub-Saharan Africa faces a growing antimicrobial resistance (AMR) threat. Antimicrobial resistant bacterial organisms pose a serious problem to human infection treatment, particularly urinary tract infections ...

Human digestive tract microbiota is a diverse community of microorganisms having complex interactions between microbes and the human host. Observing the functions carried out by microbes is essential for gaining understanding ...