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Towards cyclopalladated therapeutic oligonucleotides
(Turun yliopisto, 2021-11-19)
Based on Watson—Crick base pairing principle, therapeutic oligonucleotides bear the potential to either inhibit or alter protein synthesis. Replacing or augmenting Watson—Crick base paring by metal coordination offers a ...
Recognition of single- and double-stranded nucleic acids by covalently mercurated oligonucleotides
(Turun yliopisto, 2021-03-02)
Metal-mediated base pairs have attracted considerable attention during the past decades for their potential in bio- and nanotechnological applications. The introduction of metal ions into DNA or RNA not only stabilizes ...
Semisynthetic preparation of C‑nucleoside 5´-triphosphates as bacterial RNA polymerase substrates
(Turun yliopisto, 2021-12-18)
Interest in natural products as pharmaceutical leads has recently resurfaced due to increasing understanding towards the biosynthesis of natural compounds as well as advancements in methodologies that facilitate the ...
Synthesis of 18F-labelled radiopharmaceuticals for CNS imaging : From radiosynthesis development to GMP production
(Turun yliopisto, 2021-03-19)
Positron emission tomography (PET) is an imaging technique that can be used to follow various biological processes, such as receptor function, in a living body. PET utilisesradiopharmaceuticals, tracers containing short-lived ...
Covalent conjugates of therapeutic oligonucleotides for in vivo targeting
(Turun yliopistoAnnales Universitatis Turkuensis A I 546, 2016-09-30)
Over last few years, the development of oligonucleotide based therapeutics (antisense, siRNA, antagomirs) have received much interest as a novel class of drugs for the treatment of many diseases. Cell/organ ...
Tuning Photochromic Sodalites across the Visible Spectrum
(Turun yliopisto, 2023-06-16)
Photochromic sodalite, Na8(AlSiO4)6(Cl,S)2, has been a topic of research for almost 100 years, though only recently has a deep understanding of its remarkably fatigueresistant colour change been obtained. Aside from the ...
Reversible photochromism of synthetic hackmanites in radiation detection and quantification
(Turun yliopisto, 2023-06-12)
The subject of this thesis is centered on a mineral called hackmanite, also known as photochromic sodalite. It is found naturally in remote, mountainous places in Afghanistan, Pakistan, Greenland, Russia, Canada, and the ...
Characterization and in vitro antiparasitic activities of plant extracts containing natural and modified proanthocyanidins
(Turun yliopisto, 2023-05-05)
This thesis focused on the proanthocyanidins (PAs), a class of plant specialized metabolites that have a wide range of industrial applications. They play a vital role in the production of various food and feed products. ...
Oxidative multilayer films and eumelanin analogs for biocompatible supercapacitors
(Turun yliopisto, 2022-12-16)
The future applications of implantable electronic medical devices set heavy requirements for the materials powering the devices. They need to be biocompatible or even biodegradable and have sufficient electrochemical ...
Versatile Ultrathin Films of Conducting Polymers by Vapor Phase Polymerization at Atmospheric Pressure: Synthesis, Process Optimization, and Characterization
(Turun yliopisto, 2022-12-09)
The limitations such as toxicity, brittleness, scarcity, and high cost of currently available materials for energy storage and transparent electrode applications in bendable electronics create a need for green, sustainable, ...