Hae

During the last decades, oligonucleotides (ONs) have emerged as an alternative therapeutic modality for a variety of diseases. They can target disease mechanisms that are considered undruggable by small molecular drugs ...

The growing environmental crisis has strengthened interest in conversion technologies within the chemical industry, particularly in the reducing of greenhouse gases and minimizing toxic chemicals. To combat these issues, ...

The chemical diversity of red wine is caused by the natural compounds that originate from grapes, and the further derivatives or adducts of the natural compounds that are formed during wine making and storage. Grapes are ...

This thesis work focused on a specialized plant metabolite group called hydrolysable tannins with the aim of expanding the knowledge on their hydrophobicity, interactions with lipid membranes and antibacterial capacity. ...

Antisense oligonucleotides (ASOs) leverage the natural catalytic activity of RNases H to target specific RNA sequences for degradation. However, the challenge lies in incorporating chemical modifications into ASOs to enhance ...

Vedessä tapahtuvia kytkentäreaktioita hyödynnetään modernissa lääkekehityksen kemiassa ja bioteknologisissa sovelluksissa. Esimerkiksi DNA-templatoidun synteesin avulla valmistetaan laajoja molekyylikirjastoja, jotka ...

Positron emission tomography (PET) is a sensitive and non-invasive molecular imaging modality with various applications, including drug discovery and the development of novel therapeutics evaluation at an early stage. ...

Guanosine-5'-triphosphate (GTP) is an essential molecule for cell survival and function. Although free GTP plays a crucial role in several cellular processes, most studies focus solely on the protein bound GTP and its ...