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Aineistot 701-710 / 1059
HLA-A*24 and B*39 alleles in type 1 diabetes risk
(Turun yliopisto, 2020-12-11)
Type 1 diabetes is an autoimmune disease, and it is one of the most common chronic diseases of childhood. An asymptomatic pre-diabetes period preceding the clinical onset is characterized by autoantibodies against pancreatic ...
Geographic origin and the cardiovascular risk profile – The Cardiovascular Risk in Young Finns Study
(Turun yliopisto, 2020-09)
Background: Since the 1940’s, coronary heart disease (CHD) has been recognized as a major cause of death in the developed countries. Men born in eastern Finland were found to have internationally high CHD mortality in the ...
Crosstalk between cell adhesion and the actin cytoskeleton
(Turun yliopisto, 2020-09-25)
In order to form tissues and to move, cells need to attach to the surrounding environment. Integrins are the major cell adhesion receptors that cells use to attach to the extracellular matrix on the outside of the cell, ...
Centralisation of very preterm deliveries and benchmarking of neonatal care
(Turun yliopisto, 2020-10-03)
The care of very preterm infants is demanding, and the outcomes are superior when these infants are delivered in hospitals with the highest standard of care. This often requires transfer of the expectant mother when very ...
Long-term CPAP use in obstructive sleep apnea : Effects on cardiovascular outcomes, weight control and motor vehicle accidents
(Turun yliopisto, 2020-10-02)
Obstructive sleep apnea (OSA) is a common disorder associated with various adverse health effects, including an increased risk of cardiovascular disease (CVD) events, metabolic dysregulation, and motor vehicle accidents ...
Old acquaintances and new perspectives into testicular development and function
(Turun yliopisto, 2020-11-27)
Testicular development and function are complex processes that involve synchronization of the proliferation, apoptosis, and differentiation of specific somatic and germ cells to ensure lifelong fertility. Dysregulation of ...
Effect of antimycotics and rifampicin on the pharmacokinetics of buprenorphine and the feasibility of sublingual fentanyl for procedural sedation
(Turun yliopisto, 2020-09-04)
Buprenorphine and fentanyl are opioids, which have been clinically used for decades. Buprenorphine is traditionally prescribed for maintenance therapy in opioid dependent patients and to a lesser extent in the treatment ...
Evaluation of 68Ga-labeled PET radiopharmaceuticals for imaging of αvβ3 integrin and vascular adhesion protein-1 in inflammation and cancer
(Turun yliopisto, 2021-02-19)
Inflammation is involved in the pathogenesis of several chronic diseases as well as in the development of cancer. Vascular adhesion protein-1 (VAP-1) is an inflammation inducible endothelial adhesion molecule that participates ...
Body size, body composition and glucose tolerance with special reference to adult height, body surface area, fat and lean body mass
(Turun yliopisto, 2021-09-03)
Body size and body composition have long interested mankind and their assessments are considered key factors for the evaluation of overall health status. Although the role of obesity – mostly applying body mass index (BMI) ...
Preclinical evaluation of novel radiopharmaceuticals for positron emission tomography imaging of animal models of multiple sclerosis
(Turun yliopisto, 2020-11-06)
Multiple sclerosis (MS) is the most common autoimmune disease of central nervous system (CNS) that causes chronic neurological impairment and clinical disability. Neuroinflammation is a major element in MS pathology and ...