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Pain management in paediatric spinal surgery
(Turun yliopisto, 2019-12-13)
Posterior spinal fusion is one of the most common major surgical procedures performed in children and adolescents. Pain control can be challenging owing to the extensive posterior exposure and major tissue trauma. Therefore, ...
Inhaled xenon neuro- and cardioprotection following out-of-hospital cardiac arrest. A randomized, controlled trial
(Turun yliopisto, 2019-10-26)
Cardiac arrest leads often to death or permanent neurological damage, despite prompt advanced life support and resuscitation. Ischaemia-reperfusion injury persists, although circulation and cardiac function has been restored. ...
Pharmacokinetics and effects of extravascularly administered dexmedetomidine : studies on pediatric and adult patients, and healthy adult volunteers
(Turun yliopisto, 2019-11-01)
Patients undergoing surgery and other invasive procedures need sedation and pain relief. Many unpleasant sensations and experiences can be reduced by administration of conventional sedative and analgesic drugs, but most ...
Probing the (Un)Conscious Brain : EEG and PET Studies on Healthy Human Subjects Using Propofol, Dexmedetomidine and Natural Sleep
(Turun yliopisto, 2022-09-09)
Consciousness cannot be objectively measured. By employing anesthesia and
neurophysiologic measurements to study human consciousness, unconsciousness
has been found to associate with suppression of regional brain activity ...
Non-conveyance and patient safety in prehospital emergency care
(Turun yliopisto, 2022-10-07)
Emergency medical services (EMS) and emergency departments (EDs) have reported increased attendance rates and numbers of patients without urgent need for treatment. Because of controversy about the unnecessary conveyance ...
Effect of antimycotics and rifampicin on the pharmacokinetics of buprenorphine and the feasibility of sublingual fentanyl for procedural sedation
(Turun yliopisto, 2020-09-04)
Buprenorphine and fentanyl are opioids, which have been clinically used for decades. Buprenorphine is traditionally prescribed for maintenance therapy in opioid dependent patients and to a lesser extent in the treatment ...
Data collection in helicopter emergency medical services
(Turun yliopisto, 2021-05-28)
Prehospital critical care, especially helicopter emergency medical services (HEMS), is a costly but vital part in the chain of survival for a critically deteriorated patient. The quality assessment and outcome measures of ...
Temporal trends and outcomes in aortic and mitral valve surgery in Finland
(Turun yliopisto, 2022-01-21)
Aortic valve surgery is the most common type of heart valve surgery in western countries. The main causes for aortic valve surgery are aortic valve stenosis and regurgitation. Mitral valve regurgitation is the most common ...
Paediatric spinal surgery and perioperative management
(Turun yliopisto, 2023-05-26)
The aim of this dissertation is to improve perioperative management of adolescent patients undergoing posterior spinal fusion surgery. Posterior spinal fusion surgery is one of the most common major surgical procedures in ...
The effects of dexmedetomidine on cerebral glucose metabolism, systemic cytokine release and cerebral autoregulation: Studies on healthy volunteers and aneurysmal subarachnoid haemorrhage patients
(Turun yliopisto, 2022-12-02)
Dexmedetomidine is a very selective α2-agonist that has become a popular sedative in the intensive care unit. It has characteristics that make it appealing especially for neurologically compromised patients. Aneurysmal ...