Selaus oppiaineen mukaan kokoelmassa Opinnäytetöiden tiivistelmät (ei kokotekstiä) Bioinformatics
Aineistot 1-20 / 20
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ADMET and adverse effects predictive modeling based on FDA-approved drugs Data
(Turun yliopisto, 31.01.2017)Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) properties and adverse effects determine the success of each drug. These factors play an important role in the late-stage failure of drug candidates and ... -
Adopting the Vaadin Java framework to rebuild VTT’s Web Interfaces and Database Applications
(Turun yliopisto, 14.12.2015)With the growth in new technologies, using online tools have become an everyday lifestyle. It has a greater impact on researchers as the data obtained from various experiments needs to be analyzed and knowledge of programming ... -
Analysis of Alpha CA Genes in Early Vertebrates and ; High-Invertebrates
(Turun yliopisto, 08.06.2016)Carbonic anhydrases are enzymes that are ubiquitously found in all organisms that are engaged in catalyzing the hydration of carbon dioxide to form bicarbonate and proton and vice versa. They are crucial in the process of ... -
Analysis of the Phosphoproteome of Jnk1-/- vs Wild Type Mouse Brain Provides Novel Insight on JNK1's Interaction Profile and Its Connection to Various Mental Disorders
(Turun yliopisto, 05.03.2018)c-Jun N-terminal kinases (JNKs) are multifunctional kinases that are involved in various diseases. The JNK pathway plays a major role in cell death in response to a variety of stimuli; it hence plays a part in diseases ... -
Annotation of Gyrodactylus salaris transcriptome
(Turun yliopisto, 15.06.2016)Relationship between organisms within an ecosystem is one of the main focuses in the study of ecology and evolution. For instance, host-parasite interactions have long been under close interest of ecology, evolutionary ... -
Comparison of five popular normalization methods using a spike-in proteomics data set
(Turun yliopisto, 18.08.2016)Mass spectrometry (MS)-based proteomics has seen significant technical advances during the past two decades and mass spectrometry has become a central tool in many biosciences. Despite the popularity of MS-based methods, ... -
Comparison of peptide peak intensity methods for label free relative protein quantification
(Turun yliopisto, 21.02.2018)During the recent years, Liquid chromatography-mass spectrometry (LC-MS) has gained enormous attention to identify and quantify peptides in biological samples. The Current challenge is to quantify the level of proteins as ... -
Computational inference of functional relationships from multiple genomes : Drosophila carbonic anhydrases.
(Turun yliopisto, 24.09.2018)Carbonic anhydrases (CAHs) are metalloenzymes which catalyze the reversible chemical reaction between carbon dioxide and water to bicarbonate and a proton, which is crucial in pH homeostasis. There are several CAH families ... -
De novo transcriptome assembly and annotation of the isopod Idotea balthica
(Turun yliopisto, 24.05.2016)The Baltic Sea is a unique environment that contains unique genetic populations. In order to study these populations on a genetic level basic molecular research is needed. The aim of this thesis was to provide a basic ... -
Genomic comparisons of carbonic anhydrase V genes in vertebrates
(Turun yliopisto, 11.07.2018)Carbonic anhydrases are involved in many processes of life, have been discovered in every living organism, and are widely distributed in tissues. Carbonic anhydrases are involved in different biochemical processes, such ... -
Human Ezrin: Prediction of the 3D structure and interactions with mTOR
(Turun yliopisto, 15.06.2016)The protein Ezrin, is a member of the ERM family (Ezrin, Radixin and Moesin) that links the F-actin to the plasma membrane. The protein is made of three domains namely the FERM domain, a central α-helical domain and the ... -
Implementation of Quantitative Reaction-based Model Refinement
(Turun yliopisto, 13.10.2015)Building a computational model for complex biological systems is an iterative process. It starts from an abstraction of the process and then incorporates more details regarding the specific biochemical reactions which ... -
In silico metabolic modelling of Saccharomyces cerevisiae for the overproduction of succinate using OptKnock and OptGene
(Turun yliopisto, 08.06.2016)Succinate is a naturally occurring metabolite in organism’s cell and is industrially important chemical with various applications in food and pharmaceutical industry. It is also widely used to produce bio-degradable plastics, ... -
Machine Learning Methods for the Classification of Endometriosis
(Turun yliopisto, 05.03.2018)Endometriosis is a benign disorder estimated to affect 10% of women during their reproductive years. The main method for the diagnosis of endometriosis currently used by the clinicians is laparoscopic inspection followed ... -
Molecular modeling studies of Escherichia coli MurA towards novel Mur enzyme inhibitors against resistant bacterial strains
(Turun yliopisto, 21.12.2016)Currently more and more antibiotics are put into clinical use; meanwhile bacteria also develop diverse antibiotic resistance. MurA, a key enzyme on cell wall precursor biosynthesis pathway, was effectively inhibited by a ... -
Optimization and Applications of Large-Scale Biomedical Event Networks
(Turun yliopisto, 01.06.2016)The overwhelming amount and unprecedented speed of publication in the biomedical domain make it difficult for life science researchers to acquire and maintain a broad view of the field and gather all information that would ... -
Phylogenetic Analysis of Avidins and Expression of Novel Avidins from Lactrodectus hesperus and Hoeflea phototrophica
(Turun yliopisto, 05.11.2015)Avidins (Avds) are homotetrameric or homodimeric glycoproteins with typically less than 130 amino acid residues per monomer. They form a highly stable, non-covalent complex with biotin (vitamin H) with Kd = 10-15 M (for ... -
Prediction of Phosphorylation Sites from Protein Sequences
(Turun yliopisto, 15.06.2016)Phosphorylation is amongst the most crucial and well-studied post-translational modifications. It is involved in multiple cellular processes which makes phosphorylation prediction vital for understanding protein functions. ... -
Probing MST1 Kinase Sequence and Structure for Rational Drug Discovery (Targeting diabetes by blocking protein-protein interactions)
(Turun yliopisto, 26.04.2016)Apoptotic beta cell death is an underlying cause majorly for type I and to a lesser extent for type II diabetes. Recently, MST1 kinase was identified as a key apoptotic agent in diabetic condition. In this study, I have ... -
Structural and Mechanistic Studies of Phosphoserine Aminotransferase
(Turun yliopisto, 11.12.2015)Phosphoserine aminotrasferase (PSAT: EC 2.6.1.52) is a vitamin B6-dependent enzyme and a member of the subgroup IV in the aminotransferase superfamily. Here, X-ray crystallography was used to determine the structure of ...