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Uni- ja hengityskeskus yhtenäistää diagnostiikkaa ja hoitoa
<p>Hengitysvajeen sekä uni- ja vireystilahäiriöiden hoidossa tarvitaan useiden erikoisalojen moniammatillista yhteistyötä. Kansallisella koordinaatiolla haetaan kustannustehokkuutta ja potilaiden yhdenvertaisuuden toteutumista. ...
Rifampicin decreases exposure to sublingual buprenorphine in healthy subjects
<p>Fam3c, a
cytokine-like protein, is a member of the Fam3 family (family with
sequence similarity 3) and has been implicated to play a crucial role in
Epithelial-to- mesenchymal transition (EMT) and subsequent ...
Cementing does not increase the immediate postoperative risk of death after total hip arthroplasty or hemiarthroplasty: a hospital-based study of 10,677 patients
<p>Background and purpose: It has been suggested that cemented arthroplasty is associated with increased peri- and postoperative mortality due to bone cement implanting syndrome, especially in fracture surgery. We investigated ...
Voriconazole greatly increases the exposure to oral buprenorphine
<p>Purpose: Buprenorphine has low oral bioavailability. Regardless of sublingual administration, a notable part of buprenorphine is exposed to extensive first-pass metabolism by the cytochrome P450 (CYP) 3A4. As drug ...
High angular resolution diffusion-weighted imaging in mild traumatic brain injury
We sought to investigate white matter abnormalities in mild traumatic brain injury (mTBI) using diffusion-weighted magnetic resonance imaging (DW-MRI). We applied a global approach based on tract-based spatial statistics ...
Regional brain morphometry in patients with traumatic brain injury based on acute- and chronic-phase magnetic resonance imaging
Traumatic brain injury (TBI) is caused by a sudden external force and can be very heterogeneous in its manifestation. In this work, we analyse T1-weighted magnetic resonance (MR) brain images that were prospectively acquired ...
Voriconazole more likely than posaconazole increases plasma exposure to sublingual buprenorphine causing a risk of a clinically important interaction
This study aimed to determine possible effects of voriconazole and posaconazole on the pharmacokinetics and pharmacological effects of sublingual buprenorphine.We used a randomized, placebo-controlled crossover study design ...
Basal and cold-induced fatty acid uptake of human brown adipose tissue is impaired in obesity
<p>atty acids (FA) are important substrates for brown adipose tissue (BAT)
metabolism, however, it remains unclear whether there exists a
difference in FA metabolism of BAT between lean and obese healthy
humans. In ...
Single-subject analysis of N400 event-related potential component with five different methods
<p>There are several different approaches to analyze event-related potentials (ERPs) at single-subject level, and the aim of the current study is to provide information for choosing a method based on its ability to detect ...