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Serum cytokine profile of pediatric patients with laboratory confirmed pneumococcal meningitis
Background: Streptococcus pneumoniae infection is a leading cause of bacterial meningitis in children with severe sequelae. Cytokines are important molecules in regulating of host inflammatory and antiinflammatory responses. ...
The Impacts of Fish Oil and/or Probiotic Intervention on Low-Grade Inflammation, IGFBP-1 and MMP-8 in Pregnancy: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial
Background: We investigated the impact of fish oil and/or probiotics on serum and vaginal inflammatory and metabolic proteins and their relation to the onset of gestational diabetes mellitus (GDM). Methods: Overweight/obese ...
Granulocyte colony-stimulating factor- and chemotherapy-induced large-vessel vasculitis: six patient cases and a systematic literature review
<div>Patients receiving chemotherapy are prone to neutropoenic infections, presenting with non-specific symptoms such as a high fever and elevated inflammatory parameters. Large-vessel vasculitis (LVV) may have a similar ...
Genome sequences of RIGVIR oncolytic virotherapy virus and five other echovirus 7 isolates
<p>We report here the nearly complete Illumina-sequenced consensus genome sequences of six isolates of echovirus 7 (E7), including oncolytic virotherapy virus RIGVIR and the Wallace prototype. Amino acid identities within ...
Cholesterol lowering efficacy of plant stanol ester in a new type of product matrix, a chewable dietary supplement
Low-density lipoprotein (LDL) cholesterol lowering efficacy of a new type of chewable plant stanol ester food supplement was evaluated in a randomized, double-blind, controlled four-week intervention. The participants (LDL ...
Insights into disseminated MS brain pathology with multimodal diffusion tensor and PET imaging
<div>Objective To evaluate in vivo the co-occurrence of microglial activation and microstructural white matter (WM) damage in the MS brain and to examine their association with clinical disability.</div><div>Methods 18-kDa ...
Effect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes : The TRIGR Randomized Clinical Trial
IMPORTANCE Early exposure to complex dietary proteins may increase the risk of type 1 diabetes in children with genetic disease susceptibility. There are no intact proteins in extensively hydrolyzed formulas.OBJECTIVE To ...
Fosfataasien avulla syövän kimppuun
Syöpäsolujen sisäisten viestiverkostojen toiminnan muuttuminen on tärkeä syövän syntymekanismi ja vaikuttaa monien syöpälääkkeiden vasteisiin. Tärkein viestiverkostojen toimintaa säätelevä biokemiallinen mekanismi on ...
Pertussis Prevention: Reasons for Resurgence, and Differences in the Current Acellular Pertussis Vaccines
Pertussis is an acute respiratory disease caused by Bordetella pertussis. Due to its frequency and severity, prevention of pertussis has been considered an important public health issue for many years. The development of ...
Early overnutrition sensitizes the growth hormone axis to the impact of diet-induced obesity via sex-divergent mechanisms
In addition to its essential role in the physiological control of longitudinal growth, growth-hormone (GH) is endowed with relevant metabolic functions, including anabolic actions in muscle, lipolysis in adipose-tissue and ...